CAJ | 학술논문

临床实践中一部分梅毒患者在治疗后发生血清固定，给梅毒防治工作带来挑战。目前对于血清固定机制的认识十分有限，流行病学观察结果表明，梅毒治疗后血清学痊愈或固定与患者病期、性别、年龄、快速血浆反应素环状卡片试验(RPR)基线滴度及治疗药物有关；免疫学研究表明，血清固定患者存在免疫失衡和细胞免疫抑制。尚不清楚血清固定现象是提示患者体内有梅毒螺旋体持续性感染还是代表了一种感染诱发的机体自身免疫反应。深入研究血清固定的发病机制有助于正确处理该类患者。
림상실천중일부분매독환자재치료후발생혈청고정，급매독방치공작대래도전。목전대우혈청고정궤제적인식십분유한，류행병학관찰결과표명，매독치료후혈청학전유혹고정여환자병기、성별、년령、쾌속혈장반응소배상잡편시험(RPR)기선적도급치료약물유관；면역학연구표명，혈청고정환자존재면역실형화세포면역억제。상불청초혈청고정현상시제시환자체내유매독라선체지속성감염환시대표료일충감염유발적궤체자신면역반응。심입연구혈청고정적발병궤제유조우정학처리해류환자。
A substantial proportion of patients with syphilis who have not achieved the desired serological response and remain serofast represent a clinical challenge. To date, little is known about the exact mechanism of serological serofast. The epidemiologic analyses demonstrate serological cure or serofast state is associated with disease phase, gender, baseline RPR titers and the drug used. The immunological features of serofast state include disorder of cellar immunity and immunosuppression. Whether the serofast condition represents persistent infection of spirochetes or variability in host immune response against. Treponema pallidum is unknown. Improved understanding of the pathogenic mechanisms of the serofast condition will certainly aid in the optimal management of serofast patients.