中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
6期
1-4
,共4页
陈震宇%李巨%陈静%裴丽鹏
陳震宇%李巨%陳靜%裴麗鵬
진진우%리거%진정%배려붕
脂联素%子痫%胰岛素抵抗
脂聯素%子癇%胰島素牴抗
지련소%자간%이도소저항
Adiponectin%Eclampsia%Insulin resistance
目的 分析子痫前期孕妇血清和胎盘组织脂联素的表达及意义.方法 采用酶联免疫吸附法检测52例无妊娠并发症孕妇(对照组)、58例轻度子痫前期孕妇(轻度子痫前期组)、55例重度子痫前期孕妇(重度子痫前期组)血清脂联素,并计算稳态模型评估法胰岛素抵抗指数(HOMA-IR);采用免疫组织化学SP法检测三组孕妇胎盘组织脂联素表达情况.结果 重度子痫前期组空腹血糖明显高于对照组和轻度子痫前期组[(5.56±1.37) mmol/L比(4.55±0.51),(4.68±0.66) mmol/L],轻度子痫前期组、重度子痫前期组空腹胰岛素及HOMA-IR均高于对照组[(14.19±3.42),(14.90±6.64) mU/L比(9.87±1.75) mU/L,1.04±0.37,1.18±0.56比0.67±0.21],重度子痫前期组血清脂联素明显高于对照组和轻度子痫前期组[(15.79±4.86) mg/L比(11.47± 3.50),(11.92±2.96) mg/L],差异均有统计学意义(P＜0.05).三组胎盘组织脂联素水平比较差异均无统计学意义(P＞0.05).血清脂联素水平与HOMA-IR及胎盘组织脂联素表达无相关性(P＞0.05).结论 重度子痫前期孕妇血清脂联素、HOMA-IR明显增高,血清脂联素升高可能是子痫前期孕妇的一种适当的反馈性调节.
目的 分析子癇前期孕婦血清和胎盤組織脂聯素的錶達及意義.方法 採用酶聯免疫吸附法檢測52例無妊娠併髮癥孕婦(對照組)、58例輕度子癇前期孕婦(輕度子癇前期組)、55例重度子癇前期孕婦(重度子癇前期組)血清脂聯素,併計算穩態模型評估法胰島素牴抗指數(HOMA-IR);採用免疫組織化學SP法檢測三組孕婦胎盤組織脂聯素錶達情況.結果 重度子癇前期組空腹血糖明顯高于對照組和輕度子癇前期組[(5.56±1.37) mmol/L比(4.55±0.51),(4.68±0.66) mmol/L],輕度子癇前期組、重度子癇前期組空腹胰島素及HOMA-IR均高于對照組[(14.19±3.42),(14.90±6.64) mU/L比(9.87±1.75) mU/L,1.04±0.37,1.18±0.56比0.67±0.21],重度子癇前期組血清脂聯素明顯高于對照組和輕度子癇前期組[(15.79±4.86) mg/L比(11.47± 3.50),(11.92±2.96) mg/L],差異均有統計學意義(P＜0.05).三組胎盤組織脂聯素水平比較差異均無統計學意義(P＞0.05).血清脂聯素水平與HOMA-IR及胎盤組織脂聯素錶達無相關性(P＞0.05).結論 重度子癇前期孕婦血清脂聯素、HOMA-IR明顯增高,血清脂聯素升高可能是子癇前期孕婦的一種適噹的反饋性調節.
목적 분석자간전기잉부혈청화태반조직지련소적표체급의의.방법 채용매련면역흡부법검측52례무임신병발증잉부(대조조)、58례경도자간전기잉부(경도자간전기조)、55례중도자간전기잉부(중도자간전기조)혈청지련소,병계산은태모형평고법이도소저항지수(HOMA-IR);채용면역조직화학SP법검측삼조잉부태반조직지련소표체정황.결과 중도자간전기조공복혈당명현고우대조조화경도자간전기조[(5.56±1.37) mmol/L비(4.55±0.51),(4.68±0.66) mmol/L],경도자간전기조、중도자간전기조공복이도소급HOMA-IR균고우대조조[(14.19±3.42),(14.90±6.64) mU/L비(9.87±1.75) mU/L,1.04±0.37,1.18±0.56비0.67±0.21],중도자간전기조혈청지련소명현고우대조조화경도자간전기조[(15.79±4.86) mg/L비(11.47± 3.50),(11.92±2.96) mg/L],차이균유통계학의의(P＜0.05).삼조태반조직지련소수평비교차이균무통계학의의(P＞0.05).혈청지련소수평여HOMA-IR급태반조직지련소표체무상관성(P＞0.05).결론 중도자간전기잉부혈청지련소、HOMA-IR명현증고,혈청지련소승고가능시자간전기잉부적일충괄당적반궤성조절.
Objective To analyze the expression and significance of adiponectin in serum and placenta tissue in preeclampsia pregnancy women.Methods Serum adiponectin levels were measured by Enzyme-linked immuno sorbent assay (ELISA) in 52 cases of normal pregnant women (control group),58 cases of mild preeclampsia pregnancy women (mild preeclampsia group),and 55 cases of severe preeclampsia pregnancy women (severe preeclampsia group).Insulin resistance was estimated using the homeostatic model assessment-insulin resistance index (HOMA-IR).The expression of adiponectin in placenta tissue was detected by immunohistochemical SP methods in three groups.Results Fasting glucose level in severe preeclampsia group was higher than that in control group and mild preeclampsia group [(5.56 ± 1.37) mmol/L vs.(4.55 ± 0.51),(4.68 ± 0.66) mmol/L],fasting insulin level and HOMA-IR in mild preeclampsia group and severe preeclampsia group were higher than those in control group [(14.19 ±3.42),(14.90 ±6.64) mU/L vs.(9.87 ± 1.75) mU/L,1.04 ±0.37,1.18 ±0.56 vs.0.67 ±0.21],serum adiponectin level in severe preeclampsia group was higher than that in control group and mild preeclampsia group [(15.79 ± 4.86) mg/L vs.(11.47 ±3.50),(11.92 ± 2.96) mg/L],the differences were statistical significance (P ＜ 0.05).There was no difference of adiponectin expression levels in placenta tissue among three groups (P ＞0.05).There was no significant correlations between serum adiponectin level and HOMA-IR,expression levels of adiponectin in placenta tissue(P ＞ 0.05).Conclusions Serum adiponectin levels and HOMA-IR are higher in the severe preeclampsia pregnancy women.Increased serum adiponectin levels may be an appropriate feedback regulation in preeclampsia pregnancy women.
