CAJ | 학술논문

　　目的：探讨伴频发室早高血压病患者射频消融术后心功能的变化方法：收集2009年1月~2011年3月间在我院就诊并行射频消融治疗的频发室早患者38例，其中21例特发性室早患者作为对照组，17例伴有频发室早高血压病患者列为病例组；所有患者分别于术前及术后3月、6月、12月采用二维心脏超声测绘左室舒张末期内径（LVEDD）及血清氨基-末端脑钠肽（NT-proBNP）水平。结果：各组术后3月NT-proBNP值分别为：140.4pg/ml及153.1pg/ml，较术前明显下降（P＜0.05）；但术后12月与3月比较差异无统计学意义。各组术后3月LVEDD较术前无明显变化；术后6月两组LVEDD值分别为：（47.2±3.1）mm 、（46.7±2.8）mm，各自与术前比较，差异有统计学意义（P＜0.01）；术后12月与6月比较LVEDD进一步缩小，但两者比较差异无统计学意义。组间NT-proBNP及LVEDD各自同期比较差异不明显。结论：伴频发室早高血压病患者行射频消融治疗心脏结构和心功能恢复较好，可尝试在临床上推广运用。
　　목적：탐토반빈발실조고혈압병환자사빈소융술후심공능적변화방법：수집2009년1월~2011년3월간재아원취진병행사빈소융치료적빈발실조환자38례，기중21례특발성실조환자작위대조조，17례반유빈발실조고혈압병환자렬위병례조；소유환자분별우술전급술후3월、6월、12월채용이유심장초성측회좌실서장말기내경（LVEDD）급혈청안기-말단뇌납태（NT-proBNP）수평。결과：각조술후3월NT-proBNP치분별위：140.4pg/ml급153.1pg/ml，교술전명현하강（P＜0.05）；단술후12월여3월비교차이무통계학의의。각조술후3월LVEDD교술전무명현변화；술후6월량조LVEDD치분별위：（47.2±3.1）mm 、（46.7±2.8）mm，각자여술전비교，차이유통계학의의（P＜0.01）；술후12월여6월비교LVEDD진일보축소，단량자비교차이무통계학의의。조간NT-proBNP급LVEDD각자동기비교차이불명현。결론：반빈발실조고혈압병환자행사빈소융치료심장결구화심공능회복교호，가상시재림상상추엄운용。
Objective The purpose of this study was to investigate the changes in heart function of radiofrequen-cy catheter ablation in hypertensive patients with frequent PVC. Methods Thirty-eight consecutive patients undergo-ing Ea-guided radiofrequency catheter ablation (RFCA) were studied of whom twenty-one consective patients had Id-iopathic frequent PVC(as control group);seventeen hypertensive patients with frequent pvc(as case group). Echocar-diographic measurements of Left ventricular end-diastolic diameter size (LVEDD) and measures of the serum N-ter-minal brain natriuretic peptide (NT-proBNP) level of all the patients were obtained at baseline and after 3 months, 6 months, 12 months of RFCA. Results The NT-proBNP level of the two groups after 3 months of RFCA was significant-ly lower than basic level, respectively,( case group:153.1 vs 195.7pg/ml, P<0.01;contral goup:140.4 vs 180.3 pg/ml, P<0.05). But NT-proBNP level was no significant difference between the 12 months and 3 months after RFCA.In each groups, the LVEDD was no significant difference between the baseline and the 3 months after RFCA;LVEDD of 6 months after RFCA was much smaller than basic line in each group (case group:46.7±2.8 mm vs 52.9±3.8mm, P<0.01;control group:47.2±3.1mm vs 53.0±4.2mm, P<0.01).The LVEDD showed downward trend compared with the 12-month to 6 moths affter RFCA;but had no significant difference between them.NT-proBNP level and LVEDD was no notable difference btween the two groups at the same period, respectively. Conclusion It is effective of RFCA in hypertensive patients with frequent PVC,so can be extensivly used in clinical.