中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2013年
12期
819-823
,共5页
王帅%王银萍%郝彦勇%郑彦
王帥%王銀萍%郝彥勇%鄭彥
왕수%왕은평%학언용%정언
淋巴瘤,非霍奇金%淋巴瘤,大B-细胞,弥漫性%抗原,CD40%预后
淋巴瘤,非霍奇金%淋巴瘤,大B-細胞,瀰漫性%抗原,CD40%預後
림파류,비곽기금%림파류,대B-세포,미만성%항원,CD40%예후
Lymphoma,non-Hodqkin%Lymphoma,large B-cell,diffuse%Antigens,CD40%Prognosis
目的 观察CD40在弥漫性大B细胞淋巴瘤(DLBCL)组织中的表达,探讨其与各种临床因素、临床病理特征以及预后的关系.方法 回顾性分析吉林省肿瘤医院2008年1月至2012年10月间诊断的DLBCL87例,应用免疫组织化学SP法检测CD40的表达情况,并且详细记录每位患者的临床特征、无病生存期和总生存期.应用统计软件对CD40在DLBCL中的表达情况、各临床因素及CD40与总生存期关系的数据进行分析.结果 CD40阳性的DLBCL患者具有年龄低、临床分期早、结外受累数少、国际预后指数(IPI)小、美国东部肿瘤协作组(ECOG)评分小的特点.但在性别与发病部位无明显相关性(P=0.141和0.729).CD40阳性的患者总生存期显著高于阴性者.单因素分析结果显示DLBCL患者的预后与CD40表达、年龄、ECOG评分、IPI、结外受累数、乳酸脱氢酶(LDH)值等密切相关(均P＜0.05).分层分析结果显示无论何种免疫表型CD40阳性的患者对比同种免疫表型组都具有更好的预后.COX模型多因素分析显示CD40表达同免疫分型、ECOG评分、临床分期、治疗方案与预后密切相关(均P ＜0.05).结论 CD40可以作为DLBCL患者预后的指标,CD40阳性提示预后较好.
目的 觀察CD40在瀰漫性大B細胞淋巴瘤(DLBCL)組織中的錶達,探討其與各種臨床因素、臨床病理特徵以及預後的關繫.方法 迴顧性分析吉林省腫瘤醫院2008年1月至2012年10月間診斷的DLBCL87例,應用免疫組織化學SP法檢測CD40的錶達情況,併且詳細記錄每位患者的臨床特徵、無病生存期和總生存期.應用統計軟件對CD40在DLBCL中的錶達情況、各臨床因素及CD40與總生存期關繫的數據進行分析.結果 CD40暘性的DLBCL患者具有年齡低、臨床分期早、結外受纍數少、國際預後指數(IPI)小、美國東部腫瘤協作組(ECOG)評分小的特點.但在性彆與髮病部位無明顯相關性(P=0.141和0.729).CD40暘性的患者總生存期顯著高于陰性者.單因素分析結果顯示DLBCL患者的預後與CD40錶達、年齡、ECOG評分、IPI、結外受纍數、乳痠脫氫酶(LDH)值等密切相關(均P＜0.05).分層分析結果顯示無論何種免疫錶型CD40暘性的患者對比同種免疫錶型組都具有更好的預後.COX模型多因素分析顯示CD40錶達同免疫分型、ECOG評分、臨床分期、治療方案與預後密切相關(均P ＜0.05).結論 CD40可以作為DLBCL患者預後的指標,CD40暘性提示預後較好.
목적 관찰CD40재미만성대B세포림파류(DLBCL)조직중적표체,탐토기여각충림상인소、림상병리특정이급예후적관계.방법 회고성분석길림성종류의원2008년1월지2012년10월간진단적DLBCL87례,응용면역조직화학SP법검측CD40적표체정황,병차상세기록매위환자적림상특정、무병생존기화총생존기.응용통계연건대CD40재DLBCL중적표체정황、각림상인소급CD40여총생존기관계적수거진행분석.결과 CD40양성적DLBCL환자구유년령저、림상분기조、결외수루수소、국제예후지수(IPI)소、미국동부종류협작조(ECOG)평분소적특점.단재성별여발병부위무명현상관성(P=0.141화0.729).CD40양성적환자총생존기현저고우음성자.단인소분석결과현시DLBCL환자적예후여CD40표체、년령、ECOG평분、IPI、결외수루수、유산탈경매(LDH)치등밀절상관(균P＜0.05).분층분석결과현시무론하충면역표형CD40양성적환자대비동충면역표형조도구유경호적예후.COX모형다인소분석현시CD40표체동면역분형、ECOG평분、림상분기、치료방안여예후밀절상관(균P ＜0.05).결론 CD40가이작위DLBCL환자예후적지표,CD40양성제시예후교호.
Objective To study the expression of CD40 in diffuse large B-cell lymphoma (DLBCL) and its relationship with various clinical parameters,pathologic findings and prognostic data.Methods The clinical information of 87 patients with DLBCL diagnosed in Jilin Province Cancer Hospital during the period from January,2008 to october,2012 was retrospectively reviewed,Immunohistochemical study using SP technique for CD40 was carried out.The correlation between clinicopathologic findings,CD40 expression and survival data was analyzed using statistical software.Results Cases of CD40-positive DLBCL were characterized by lower age group,early clinical stage,less extranodal involvement,lower IPI index and lower ECOG score.However,there was no significant correlation between gender of patients and site of involvement (P =0.141 and 0.729).The overall survival of patients with CD40-positive DLBCL was significantly higher than that in patients with CD40-negative DLBCL.One-way analysis of variance showed that the prognosis of DLBCL was closely associated with CD40 expression,age of patients,ECOG score,IPI index,extranodal involvement and LDH level (P ＜ 0.05,respectively).Stratified analysis showed that CD40-positive DLBCL carried a better prognosis,irrespective of other immunophenotyping results.COX model multivariate analysis showed that the expression of CD40 closely correlated with other immunophenotyping results,ECOG score,clinical staging,treatment regimen and prognosis (P ＜ 0.05).Conclusion The expression of CD40 is a favorable prognostic indicator in patients with DLCBL.
