中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
6期
4-6
,共3页
婴儿,新生%肺炎%高流量鼻导管湿化氧疗
嬰兒,新生%肺炎%高流量鼻導管濕化氧療
영인,신생%폐염%고류량비도관습화양료
Infant,newborn%Pneumonia%Humidified high flow nasal cannula
目的 探讨高流量鼻导管湿化氧疗(HHFNC)对新生儿重症肺炎的治疗效果.方法 将42例新生儿重症肺炎患儿根据治疗方法不同分为治疗组20例和对照组22例,治疗组给予HHFNC治疗；对照组给予经湿化瓶鼻导管或面罩给氧治疗.比较两组患儿主要症状体征消失时间、住院时间及治疗组HHFNC应用前后脉搏血氧饱和度(SpO2)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、呼吸频率等指标的改善情况.结果 治疗组有效率显著高于对照组[90.00％(18/20)比63.64％(14/22)],差异有统计学意义(P＜0.05).治疗组主要症状体征消失时间及住院时间明显短于对照组,机械通气率较对照组明显降低[10.00％(2/20)比45.45％(10/22)],差异均有统计学意义(P＜0.05)；HHFNC应用后12,24 h和撤离HHFNC后1h的SpO2及PaO2均较HHFNC应用前显著升高[0.921±0.027,0.955±0.021,0.958±0.016比0.865±0.045,(83.4±28.3),(89.8±20.4),(92.8±12.6) mmHg(1mmHg =0.133 kPa)比(52.8±10.1) mmHg],HHFNC应用后24h及撤离HHFNC后1 h PaCO2较HHFNC应用前显著降低[(46.1±6.3),(43.7± 7.2) mmHg比(59.7±8.3) mmHg],差异均有统计学意义(P＜0.05).呼吸频率随治疗时间点的推移进行性下降,差异均有统计学意义(P＜0.05).结论 应用HHFNC治疗新生儿重症肺炎疗效确切,值得推广.
目的 探討高流量鼻導管濕化氧療(HHFNC)對新生兒重癥肺炎的治療效果.方法 將42例新生兒重癥肺炎患兒根據治療方法不同分為治療組20例和對照組22例,治療組給予HHFNC治療；對照組給予經濕化瓶鼻導管或麵罩給氧治療.比較兩組患兒主要癥狀體徵消失時間、住院時間及治療組HHFNC應用前後脈搏血氧飽和度(SpO2)、動脈血氧分壓(PaO2)、動脈血二氧化碳分壓(PaCO2)、呼吸頻率等指標的改善情況.結果 治療組有效率顯著高于對照組[90.00％(18/20)比63.64％(14/22)],差異有統計學意義(P＜0.05).治療組主要癥狀體徵消失時間及住院時間明顯短于對照組,機械通氣率較對照組明顯降低[10.00％(2/20)比45.45％(10/22)],差異均有統計學意義(P＜0.05)；HHFNC應用後12,24 h和撤離HHFNC後1h的SpO2及PaO2均較HHFNC應用前顯著升高[0.921±0.027,0.955±0.021,0.958±0.016比0.865±0.045,(83.4±28.3),(89.8±20.4),(92.8±12.6) mmHg(1mmHg =0.133 kPa)比(52.8±10.1) mmHg],HHFNC應用後24h及撤離HHFNC後1 h PaCO2較HHFNC應用前顯著降低[(46.1±6.3),(43.7± 7.2) mmHg比(59.7±8.3) mmHg],差異均有統計學意義(P＜0.05).呼吸頻率隨治療時間點的推移進行性下降,差異均有統計學意義(P＜0.05).結論 應用HHFNC治療新生兒重癥肺炎療效確切,值得推廣.
목적 탐토고류량비도관습화양료(HHFNC)대신생인중증폐염적치료효과.방법 장42례신생인중증폐염환인근거치료방법불동분위치료조20례화대조조22례,치료조급여HHFNC치료；대조조급여경습화병비도관혹면조급양치료.비교량조환인주요증상체정소실시간、주원시간급치료조HHFNC응용전후맥박혈양포화도(SpO2)、동맥혈양분압(PaO2)、동맥혈이양화탄분압(PaCO2)、호흡빈솔등지표적개선정황.결과 치료조유효솔현저고우대조조[90.00％(18/20)비63.64％(14/22)],차이유통계학의의(P＜0.05).치료조주요증상체정소실시간급주원시간명현단우대조조,궤계통기솔교대조조명현강저[10.00％(2/20)비45.45％(10/22)],차이균유통계학의의(P＜0.05)；HHFNC응용후12,24 h화철리HHFNC후1h적SpO2급PaO2균교HHFNC응용전현저승고[0.921±0.027,0.955±0.021,0.958±0.016비0.865±0.045,(83.4±28.3),(89.8±20.4),(92.8±12.6) mmHg(1mmHg =0.133 kPa)비(52.8±10.1) mmHg],HHFNC응용후24h급철리HHFNC후1 h PaCO2교HHFNC응용전현저강저[(46.1±6.3),(43.7± 7.2) mmHg비(59.7±8.3) mmHg],차이균유통계학의의(P＜0.05).호흡빈솔수치료시간점적추이진행성하강,차이균유통계학의의(P＜0.05).결론 응용HHFNC치료신생인중증폐염료효학절,치득추엄.
Objective To explore the effect of humidified high flow nasal cannula (HHFNC) in neonatal with severe pneumonia.Methods Forty-two cases of neonatal with severe pneumonia according to different treatment methods were divided into treatment group (20 cases) and control group (22 cases).Treatment group was given HHFNC,control group was given the wet bottle oxygen nasal cannula or mask.Disappearance of symptoms and hospital stay in two groups,blood oxygen saturation (SpO2),partial pressure of oxygen (PaO2),partial pressure of earbondioxidc (PaCO2) and respiratory rate in treatment group before and after the application of HHFNC were compared.Results The effective rate in treatment group was significantly higher than that in control group [90.00％ (18/20) vs.63.64％ (14/22)],which reached statistical significance (P ＜0.05).Disappearance of symptoms and hospital stay in treatment group were shorter than those in control group,and mechanical ventilation rate was lower than that in control group [10.00％(2/20) vs.45.45％(10/22)],which reached statistical significance (P ＜ 0.05).SpO2 and PaO2 at application of HHFNC after 12,24 h and 1 h after evacuation of HHFNC were significantly increased eompared with those before [0.921 ± 0.027,0.955 ± 0.021,0.958 ± 0.016 vs.0.865 ± 0.045; (83.4 ± 28.3),(89.8 ±20.4),(92.8 ±12.6) mmHg (1 mmHg =0.133 kPa) vs.(52.8 ±10.1) mmHg],PaCO2 at application of HHFNC after 24 h and 1 h after evacuation of HHFNC were significantly reduced compared with those before [(46.1 ±6.3),(43.7 ±7.2) mmHg vs.(59.7 ± 8.3) mmHg],which reached statistical significance (P ＜0.05).Respiratory rate was decreased with the treatment time,which reached statistical significance (P＜ 0.05).Conclusion Application of HHFNC in neonatal with severe pneumonia is effective and woorth promoting.
