白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2013年
3期
169-171
,共3页
利钠肽,脑%蒽环类%心脏毒性%超声心动描记术
利鈉肽,腦%蒽環類%心髒毒性%超聲心動描記術
리납태,뇌%은배류%심장독성%초성심동묘기술
Natriuretic peptide,brain%Anthracyclines%Cardiotoxicity%Echocardiography
目的 探讨淋巴瘤患者血浆中脑钠肽(BNP)与葸环类药物心脏毒性的相关性.方法 选择使用蒽环类药物化疗后的36例淋巴瘤患者,分别在化疗前及葸环类药物累积剂量达200、400 mg/m2后,检测血浆脑钠肽及超声心动图各指标变化情况.结果 当蒽环类药物累积剂量达到200、400 mg/m2时,36例淋巴瘤患者血浆BNP水平为(292±7)ng/ml、(387±4)ng/ml较化疗前(134±6)ng/ml明显升高(P＜ 0.05),心室舒张功能指标[舒张早期左室充盈峰速度/收缩期左室充盈峰速度(E/A)](1.14±0.37、0.90±0.06)较化疗前(1.33±0.27)明显降低(P＜0.05),而收缩功能指标(射血分数、短轴缩短率)差异无统计学意义(P＞0.05).当蒽环类药物累积剂量达到200、400 mg/ m2时,血浆BNP水平与E/A存在负相关(r=-0.689,P=0.042;r=-0.557,P=0.006),而与射血分数、短轴缩短率不存在相关性(P＞0.05).结论 BNP作为蒽环类药物化疗心脏毒性的早期监测指标有一定临床意义.
目的 探討淋巴瘤患者血漿中腦鈉肽(BNP)與葸環類藥物心髒毒性的相關性.方法 選擇使用蒽環類藥物化療後的36例淋巴瘤患者,分彆在化療前及葸環類藥物纍積劑量達200、400 mg/m2後,檢測血漿腦鈉肽及超聲心動圖各指標變化情況.結果 噹蒽環類藥物纍積劑量達到200、400 mg/m2時,36例淋巴瘤患者血漿BNP水平為(292±7)ng/ml、(387±4)ng/ml較化療前(134±6)ng/ml明顯升高(P＜ 0.05),心室舒張功能指標[舒張早期左室充盈峰速度/收縮期左室充盈峰速度(E/A)](1.14±0.37、0.90±0.06)較化療前(1.33±0.27)明顯降低(P＜0.05),而收縮功能指標(射血分數、短軸縮短率)差異無統計學意義(P＞0.05).噹蒽環類藥物纍積劑量達到200、400 mg/ m2時,血漿BNP水平與E/A存在負相關(r=-0.689,P=0.042;r=-0.557,P=0.006),而與射血分數、短軸縮短率不存在相關性(P＞0.05).結論 BNP作為蒽環類藥物化療心髒毒性的早期鑑測指標有一定臨床意義.
목적 탐토림파류환자혈장중뇌납태(BNP)여사배류약물심장독성적상관성.방법 선택사용은배류약물화료후적36례림파류환자,분별재화료전급사배류약물루적제량체200、400 mg/m2후,검측혈장뇌납태급초성심동도각지표변화정황.결과 당은배류약물루적제량체도200、400 mg/m2시,36례림파류환자혈장BNP수평위(292±7)ng/ml、(387±4)ng/ml교화료전(134±6)ng/ml명현승고(P＜ 0.05),심실서장공능지표[서장조기좌실충영봉속도/수축기좌실충영봉속도(E/A)](1.14±0.37、0.90±0.06)교화료전(1.33±0.27)명현강저(P＜0.05),이수축공능지표(사혈분수、단축축단솔)차이무통계학의의(P＞0.05).당은배류약물루적제량체도200、400 mg/ m2시,혈장BNP수평여E/A존재부상관(r=-0.689,P=0.042;r=-0.557,P=0.006),이여사혈분수、단축축단솔불존재상관성(P＞0.05).결론 BNP작위은배류약물화료심장독성적조기감측지표유일정림상의의.
anthracycline-induced cardiotoxicity in patients with lymphoma.Methods Thirty-two adult patients with nonHodgkin' s lymphoma who received chemotherapy including anthracyclin were studied.After anthracyclin reached the cumulative doses of 200 and 400 mg/m-2,the changes in plasma BNP and echocardiography indices were investigated.Results After the cumulative anthracyclin reached doses of 200 and 400 mg/m2,serum BNP were respectively (292±7) ng/ml and (387±4) ng/ml,and were significantly increased when compared to the untreated (134±6) ng/ml (P ＜ 0.05).The parameter of diastolic functions ratio of peak early to peak late low velocity (E/A ratio)were 1.14±0.37 and 0.90±0.06,both showing significant decreases compared to the control (1.33±0.27) (P ＜ 0.05).In contrast,systolic function parameters left ventricular ejection fraction (EF) and fractional shortening (FS) remained unchanged (P ＞ 0.05).After the cumulative anthracyclin reached 200 and 400 mg/m2,significant negative correlations were observed between the plasma BNP and the E/A ratio (r =-0.689,P=0.042; r=-0.557,P =0.006),but no associations between EF and FS were found (P ＞ 0.05).Conclusion Plasma BNP concentration appears to be a sensitive parameter for the early assessment of anthracycline-induced cardiotoxicity.
