实用皮肤病学杂志
實用皮膚病學雜誌
실용피부병학잡지
JOURNAL OF PRACTRCAL DERMATOLOGY
2014年
2期
89-91
,共3页
尖锐湿疣%异维A酸%光动力疗法%激光,二氧化碳%复发
尖銳濕疣%異維A痠%光動力療法%激光,二氧化碳%複髮
첨예습우%이유A산%광동력요법%격광,이양화탄%복발
Condyloma accuminatum%Isotretinoin%ALA-PDT%Laser,CO2%Therapeutic effect%Recurrence
目的：观察口服异维A酸胶囊联合CO2激光或光动力疗法治疗尖锐湿疣的临床疗效和复发率。方法将120例门诊确诊的尖锐湿疣患者随机分为4组，每组各30例。A组行单纯光动力治疗；B组行光动力治疗联合异维A酸10 mg，每日3次口服，直到疣体完全消失，改为异维A酸10 mg，每日1次口服，维持1个月后停药；C组行单纯CO2激光治疗；D组行CO2激光治疗联合异维A酸口服，服法同B组。所有患者均每2周随访1次，记录皮损改善情况及不良反应。CO2激光或光动力疗法治疗均维持到疣体完全消失，随访6个月。结果 A组痊愈19例，显效9例，无效2例；B组痊愈26例，显效3例，无效1例；C组痊愈10例，显效13例，无效7例；D组痊愈15例,显效11例，无效4例。AB组与CD组的组内疗效比较差异有统计学意义（AB：χ2=6.788，P＜0.05；CD：χ2=6.652，P＜0.05）。4组患者的复发率分别为21.1%、11.5%、60.0%、40.0%。AB组与CD组的组内复发率比较差异有统计学意义（AB ：χ2=0.756，P＜0.05；CD：χ2=0.962，P＜0.05）。结论异维A酸联合CO2激光或光动力疗法对尖锐湿疣具有较好的治疗作用，且复发率较低。
目的：觀察口服異維A痠膠囊聯閤CO2激光或光動力療法治療尖銳濕疣的臨床療效和複髮率。方法將120例門診確診的尖銳濕疣患者隨機分為4組，每組各30例。A組行單純光動力治療；B組行光動力治療聯閤異維A痠10 mg，每日3次口服，直到疣體完全消失，改為異維A痠10 mg，每日1次口服，維持1箇月後停藥；C組行單純CO2激光治療；D組行CO2激光治療聯閤異維A痠口服，服法同B組。所有患者均每2週隨訪1次，記錄皮損改善情況及不良反應。CO2激光或光動力療法治療均維持到疣體完全消失，隨訪6箇月。結果 A組痊愈19例，顯效9例，無效2例；B組痊愈26例，顯效3例，無效1例；C組痊愈10例，顯效13例，無效7例；D組痊愈15例,顯效11例，無效4例。AB組與CD組的組內療效比較差異有統計學意義（AB：χ2=6.788，P＜0.05；CD：χ2=6.652，P＜0.05）。4組患者的複髮率分彆為21.1%、11.5%、60.0%、40.0%。AB組與CD組的組內複髮率比較差異有統計學意義（AB ：χ2=0.756，P＜0.05；CD：χ2=0.962，P＜0.05）。結論異維A痠聯閤CO2激光或光動力療法對尖銳濕疣具有較好的治療作用，且複髮率較低。
목적：관찰구복이유A산효낭연합CO2격광혹광동력요법치료첨예습우적림상료효화복발솔。방법장120례문진학진적첨예습우환자수궤분위4조，매조각30례。A조행단순광동력치료；B조행광동력치료연합이유A산10 mg，매일3차구복，직도우체완전소실，개위이유A산10 mg，매일1차구복，유지1개월후정약；C조행단순CO2격광치료；D조행CO2격광치료연합이유A산구복，복법동B조。소유환자균매2주수방1차，기록피손개선정황급불량반응。CO2격광혹광동력요법치료균유지도우체완전소실，수방6개월。결과 A조전유19례，현효9례，무효2례；B조전유26례，현효3례，무효1례；C조전유10례，현효13례，무효7례；D조전유15례,현효11례，무효4례。AB조여CD조적조내료효비교차이유통계학의의（AB：χ2=6.788，P＜0.05；CD：χ2=6.652，P＜0.05）。4조환자적복발솔분별위21.1%、11.5%、60.0%、40.0%。AB조여CD조적조내복발솔비교차이유통계학의의（AB ：χ2=0.756，P＜0.05；CD：χ2=0.962，P＜0.05）。결론이유A산연합CO2격광혹광동력요법대첨예습우구유교호적치료작용，차복발솔교저。
Objective To observe therapeutic effect and recurrence rate of oral isotretinoin with CO2-laser or ALA-PDT therapy in the treatment of condyloma accuminatum. Methods Totally 120 cases of condyloma accuminatum patients diagnosed in outpatient were randomly divided into 4 groups. Group A:30 cases, only ALA-PDT treatment. Group B:30 cases, ALA-PDT treatment with oral isotretinoin 10 mg, 3 times a day, and turning to 10 mg per day till the lesion disappearing clearly, stopping after 1 month. Group C:30 cases, only CO2-laser treatment. Group D:30 cases, CO2-laser treatment with oral isotretinoin, same to Group B. All groups have observation the other week, recorded lesion condition and adverse effect. Physical therapy until the lesion disapearing clearly. Follow up 6 months. Results Group A:19 cases heal, 9 cases excellence, 2 cases inefifcacy. Group B:26 cases heal, 3 cases excellence, 1 cases inefifcacy. Group C:10 cases heal, 13 cases excellence, 7 cases inefifcacy. Group D:15 cases heal, 11 cases excellence, 4 cases inefifcacy. There was signiifcant difference between Group AB and group CD in therapeutic effect, respectively (AB:χ2=6.788, P<0.05;CD:χ2=6.652, P<0.05). Recurrence rate:Group A:21.1%;Group B:11.5%;Group C:60.0%;Group D:40.0%. There was signiifcant difference between GroupAB and group CD in recurrence rate (AB:χ2=0.756, P<0.05;CD:χ2=0.962, P<0.05). Conclusion Oral Isotretinoin with CO2-laser or ALA-PDT has great therapeutic effect and low recurrence rate.
