CAJ | 학술논문

目的探讨溶血磷脂酸(lysophosphatidic acid,LPA)与抗心磷脂抗体(anti-cardiolipin antibody,ACA)联合检测预测妊高症疾病发展及妊娠结局的价值.方法分别采用生化法、酶联免疫法测定142例妊高症患者(其中妊娠期高血压53例,轻度子痫前期46例,重度子痫前期43例)及正常妊娠晚期孕妇(对照组58例)血浆LPA水平及抗心磷脂抗体阳性率,分析两者在不同程度妊高症患者中的差异及相关性,同时评价其与妊娠预后的关系.结果妊高症患者血浆LPA水平随病情发展依次升高,且均高于对照组(P＜0.05);重度妊高症组抗心磷脂抗体阳性率高于其他组(P＜0.05).重度妊高症患者抗心磷脂抗体阳性组血浆LPA水平明显升高,且发病孕周小,围产儿体重低,新生儿Apgar评分低,与阴性组比较,差异均有统计学意义(P＜0.05或0.01).结论妊娠期高血压疾病病情程度与血浆LPA水平相关,病情越重,LPA水平也越高.抗心磷脂抗体与重度妊高症的发病有关.LPA与ACA联合检测可早期预测妊高症的病情程度及妊娠结局,有望成为病情监测及预后判断的指标.
목적 탐토용혈린지산(lysophosphatidic acid,LPA)여항심린지항체(anti-cardiolipin antibody,ACA)연합검측예측임고증질병발전급임신결국적개치.방법 분별채용생화법、매련면역법측정142례임고증환자(기중임신기고혈압53례,경도자간전기46례,중도자간전기43례)급정상임신만기잉부(대조조58례)혈장LPA수평급항심린지항체양성솔,분석량자재불동정도임고증환자중적차이급상관성,동시평개기여임신예후적관계.결과 임고증환자혈장LPA수평수병정발전의차승고,차균고우대조조(P＜0.05);중도임고증조항심린지항체양성솔고우기타조(P＜0.05).중도임고증환자항심린지항체양성조혈장LPA수평명현승고,차발병잉주소,위산인체중저,신생인Apgar평분저,여음성조비교,차이균유통계학의의(P＜0.05혹0.01).결론 임신기고혈압질병병정정도여혈장LPA수평상관,병정월중,LPA수평야월고.항심린지항체여중도임고증적발병유관.LPA여ACA연합검측가조기예측임고증적병정정도급임신결국,유망성위병정감측급예후판단적지표.
Objective To investigate the value of the combined detection of lysophosphatidic acid (LPA) and anti-cardiolipin antibody (ACA) for forecasting the development of pregnancy hypertension disease and pregnancy outcome.Methods Euzymelinked immunosorbent assay and biochemical treatment were respectively used to determinate the LPA level in plasma and anticardiolipin antibody positive rate of 142 cases of pregnancy-induced hypertension,including 53 cases of pregnancy-induced hypertension,mild preeclampsia 46 cases,and severe preeclampsia 43 cases,and normal late pregnant women (control group,58 cases),so to analyse the differences and correlation in patients with different degree pregnancy-induced hypertension and at the same time to evaluate its relationship with pregnancy outcome.Results The plasma LPA levels in patients with pregnancyinduced hypertension syndrome increased successively with the progression of the disease and were higher than that in the control group (P ＜ 0.05) ; the anticardiolipin antibody positive rate of severe PIH group was higher than that of other groups (P ＜ 0.05).The plasma level of LPA of the patients whose anticardiolipin antibody was positive in severe PIH group increased significantly,and the gestational age was small when onset,weight of perinatal low,and neonatal Apgar score low,which statistically differed from those of the negative group (P ＜ 0.05 or 0.01).Conclusions The severity of pregnancy-induced hypertension correlates with plasma LPA level; the more severe the disease becomes,the level of LPA is higher.Anticardiolipin antibody correlates with the pathogenesis of severe PIH.The combined detection of LPA and ACA can predict the severity of pregnancyinduced hypertension syndrome and pregnancy outcome,and it is expected to become the important measure of disease monitoring and prognosis.