CAJ | 학술논문

目的评价盐酸奥普力农治疗充血性心力衰竭(CHF)临床疗效及不良反应.方法采用随机分组的方法,将94例充血性心衰患者分为奥普力农组(试验组)和米力农组(对照组),每组47例,分别予奥普力农与米力农静脉用药,观察治疗7天后血清N端前体脑钠肽(NT-proBNP)和超声心动图测量下的左心室射血分数(LVEF)、短轴缩短率(FS)、左室舒张末期直径(LVEDD)及容积(LVEDV)、收缩末期直径(LVESD)、容积(LVESV)、心排血量(C0)与心脏指数(CI)等心功能变化情况及短期预后.结果治疗7天后,两组患者血清NT-proBNP、LVEDV均较治疗前明显下降(试验组两者P值分别为0.000,0.013;对照组两者P值分别为0.000,0.014),LVEF及FS较治疗前明显升高(试验组两者P值分别为0.000,0.011；对照组两者P值分别为0.030,0.042).治疗后两组间比较,试验组NT-proBNP浓度较对照组更低(P=0.041),LVEF及FS较对照组更高(P值分别为0.048,0.047).两组患者治疗前后血小板(PLT)及肝肾功能改变均无统计学意义(P＞0.05).两组患者7天及30天死亡率之间的差异均无统计学意义(P＞0.05).结论奥普力农可使CHF病人NT-proBNP下降、心功能改善,疗效明显优于米力农,而不良反应并不增加.
목적 평개염산오보력농치료충혈성심력쇠갈(CHF)림상료효급불량반응.방법 채용수궤분조적방법,장94례충혈성심쇠환자분위오보력농조(시험조)화미력농조(대조조),매조47례,분별여오보력농여미력농정맥용약,관찰치료7천후혈청N단전체뇌납태(NT-proBNP)화초성심동도측량하적좌심실사혈분수(LVEF)、단축축단솔(FS)、좌실서장말기직경(LVEDD)급용적(LVEDV)、수축말기직경(LVESD)、용적(LVESV)、심배혈량(C0)여심장지수(CI)등심공능변화정황급단기예후.결과 치료7천후,량조환자혈청NT-proBNP、LVEDV균교치료전명현하강(시험조량자P치분별위0.000,0.013;대조조량자P치분별위0.000,0.014),LVEF급FS교치료전명현승고(시험조량자P치분별위0.000,0.011；대조조량자P치분별위0.030,0.042).치료후량조간비교,시험조NT-proBNP농도교대조조경저(P=0.041),LVEF급FS교대조조경고(P치분별위0.048,0.047).량조환자치료전후혈소판(PLT)급간신공능개변균무통계학의의(P＞0.05).량조환자7천급30천사망솔지간적차이균무통계학의의(P＞0.05).결론 오보력농가사CHF병인NT-proBNP하강、심공능개선,료효명현우우미력농,이불량반응병불증가.
Objective To evaluate the efficacy and safety of Olprinone in treatment of congestive heart failure(CHF).Methods 94 cases of CHF were randomly divided into Olprinone group and Milrinone group,47 cases in each group.Olprinone or Milrinone were prescribed for patients of two groups respectively.The change of NT-proBNP level,cardiac function measured by echocardiography including left ventricular ejection fraction(LVEF),fractional shortening(FS),left ventricular end diastolic diameter(LVEDD),left ventricular end diastolic volume(LVEDV),left ventricular end systolic diameter(LVESD),left ventricular end systolic volume(LVESV),cardiac output(CO) and cardiac index(CI) after 7 days' treatment and short-term prognosis were observed.Results NT-proBNP level,LVEDV of two groups decreased significantly(P =0.000,0.013 respectively in Olprinone group,P =0.000,0.014 respectively in Milrinone group),and LVEF and FS increased significantly(P =0.000,0.011 respectively in Olprinone group,P =0.030,0.042 respectively in Milrinone group).After 7 days' treatment,compared with Milrinone group,NT-proBNP level of Olprinone group was lower (P =0.041),and LVEF and FS were higher(P =0.048,0.047 respectively).There were no significant differences between PLT level,liver function and renal function of the two groups.The mortality of 7-day and 30-day of Olprinone group was not significantly different from that of Milrinone group.Conclusions Olprinone is better than Milrinone in the effect of depressing NT-proBNP level and improving cardiac function.Meanwhile,the incidence of side effect does not appear to be higher.