基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2013年
17期
2181-2183
,共3页
急性脑梗死%EPO%CRP%神经保护
急性腦梗死%EPO%CRP%神經保護
급성뇌경사%EPO%CRP%신경보호
Acute cerebral infarction%EPO%CRP%Neuroprotection
目的观察内源性促红细胞生成素（erythropoietin，EPO）、C-反应蛋白（CRP）在急性脑梗死（acute cerebral infarction，ACI）中水平的变化，探讨EPO可能存在的神经保护作用及机制。方法 ACI患者64例，根据头颅CT或MRI梗死灶横断面最大直径分为小梗死灶组、中梗死灶组、大梗死灶组，与正常对照组35例作对照分析。采用酶联免疫吸附试验（enzyme linked immunosorbent assay，ELISA）双抗体夹心法测定血清EPO水平；采用免疫比浊法测定血清C-反应蛋白（C-reactive Protein，CRP）水平。结果脑梗死组血清EPO及CRP水平均高于正常对照组（P<0.01）；EPO与CRP水平经直线相关分析呈负相关（r=-0.643，P<0.01）；小梗死灶组血清 EPO水平高于中、大梗死灶组（P均<0.01），中梗死灶组血清EPO水平高于大梗死灶组（P<0.05）；大梗死灶组血清CRP水平高于小、中梗死灶组（P<0.01），小梗死灶组与中梗死灶组血清CRP水平比较差异无显著性（P>0.05）。随着梗死灶的增大，血清EPO水平有逐渐降低的趋势，血清CRP水平有逐渐升高的趋势。结论内源性EPO在ACI中可能存在着一定的神经保护作用，机制之一可能是减轻脑缺血区的炎症反应。外源性EPO有望成为ACI一种新的治疗选择。
目的觀察內源性促紅細胞生成素（erythropoietin，EPO）、C-反應蛋白（CRP）在急性腦梗死（acute cerebral infarction，ACI）中水平的變化，探討EPO可能存在的神經保護作用及機製。方法 ACI患者64例，根據頭顱CT或MRI梗死竈橫斷麵最大直徑分為小梗死竈組、中梗死竈組、大梗死竈組，與正常對照組35例作對照分析。採用酶聯免疫吸附試驗（enzyme linked immunosorbent assay，ELISA）雙抗體夾心法測定血清EPO水平；採用免疫比濁法測定血清C-反應蛋白（C-reactive Protein，CRP）水平。結果腦梗死組血清EPO及CRP水平均高于正常對照組（P<0.01）；EPO與CRP水平經直線相關分析呈負相關（r=-0.643，P<0.01）；小梗死竈組血清 EPO水平高于中、大梗死竈組（P均<0.01），中梗死竈組血清EPO水平高于大梗死竈組（P<0.05）；大梗死竈組血清CRP水平高于小、中梗死竈組（P<0.01），小梗死竈組與中梗死竈組血清CRP水平比較差異無顯著性（P>0.05）。隨著梗死竈的增大，血清EPO水平有逐漸降低的趨勢，血清CRP水平有逐漸升高的趨勢。結論內源性EPO在ACI中可能存在著一定的神經保護作用，機製之一可能是減輕腦缺血區的炎癥反應。外源性EPO有望成為ACI一種新的治療選擇。
목적관찰내원성촉홍세포생성소（erythropoietin，EPO）、C-반응단백（CRP）재급성뇌경사（acute cerebral infarction，ACI）중수평적변화，탐토EPO가능존재적신경보호작용급궤제。방법 ACI환자64례，근거두로CT혹MRI경사조횡단면최대직경분위소경사조조、중경사조조、대경사조조，여정상대조조35례작대조분석。채용매련면역흡부시험（enzyme linked immunosorbent assay，ELISA）쌍항체협심법측정혈청EPO수평；채용면역비탁법측정혈청C-반응단백（C-reactive Protein，CRP）수평。결과뇌경사조혈청EPO급CRP수평균고우정상대조조（P<0.01）；EPO여CRP수평경직선상관분석정부상관（r=-0.643，P<0.01）；소경사조조혈청 EPO수평고우중、대경사조조（P균<0.01），중경사조조혈청EPO수평고우대경사조조（P<0.05）；대경사조조혈청CRP수평고우소、중경사조조（P<0.01），소경사조조여중경사조조혈청CRP수평비교차이무현저성（P>0.05）。수착경사조적증대，혈청EPO수평유축점강저적추세，혈청CRP수평유축점승고적추세。결론내원성EPO재ACI중가능존재착일정적신경보호작용，궤제지일가능시감경뇌결혈구적염증반응。외원성EPO유망성위ACI일충신적치료선택。
Objective To investigate the probable existence of neuroprotective effects and mechanism of endogenous EPO in the ACI and to provide evidences of the probability of the clinical application of EPO for curing ACI. Methods To select 64 cases of patients with acute cerebral infarction 35 cases of normal control group. The serum concentration of EPO was measured by ELISA and the serum concentration of CRP was measured by immuoturbidimetry. Results The concentrations of serum EPO、IL-6 and CRP of cerebral infarction group (CI)were higher than those of normal control group (P<0.01);According to the analysis of the bivariate correlation,there were negative correlations between EPO and CRP(r=-0.643,P<0.01);The serum concentrations of EPO of the small CI were higher than those of the medium or the large one(P<0.01),and the serum concentrations of EPO of the medium CI were higher than those of the large one (P<0.05).The more larger the cerebral infarction size became,the more lower the concentrations of serum EPO became,while the more higher the serum concentrations of CRP became. Conclusion EPO probably has some certain neuroprotective effects in the ACI.One mechanism may be to reduce the inflammatory response in cerebral ischemia. Exogenous EPO is expected to become a new treatment option.
