CAJ | 학술논문

目的根据激素性股骨头坏死的骨质疏松理论，实验性研究治疗骨质疏松药物鲑鱼降钙素对于早期激素性股骨头坏死的预防作用，并探讨其机制。方法将18只成年健康SD大鼠随机分为3组，A组：马血清+地塞米松，B组：马血清+地塞米松+鲑鱼降钙素+乐力，C组：空白对照组。A组经尾静脉注射马血清20 mL/(kg·次)，共两次，间隔3周，第二次注射马血清后两周，连续3 d腹腔内注射地塞米松注射液20 mg/(kg·d)；B组除与A组相同部分外，另在注射马血清第1天开始肌肉注射鲑鱼降钙素10 U/(kg·d)，并乐力灌胃250 mg/(kg·d)；空白对照组于相应时间相同部位注射和灌胃同等量生理盐水。结果A组股骨头较B组有较为明显的骨细胞坏死，髓腔造血细胞活跃程度也有明显的减少，A、B组均有骨坏死后的修复，但B组更为明显。结论鲑鱼降钙素联合乐力治疗，对于早期的激素性股骨头坏死有一定的预防和促进修复作用。
목적근거격소성고골두배사적골질소송이론，실험성연구치료골질소송약물해어강개소대우조기격소성고골두배사적예방작용，병탐토기궤제。방법장18지성년건강SD대서수궤분위3조，A조：마혈청+지새미송，B조：마혈청+지새미송+해어강개소+악력，C조：공백대조조。A조경미정맥주사마혈청20 mL/(kg·차)，공량차，간격3주，제이차주사마혈청후량주，련속3 d복강내주사지새미송주사액20 mg/(kg·d)；B조제여A조상동부분외，령재주사마혈청제1천개시기육주사해어강개소10 U/(kg·d)，병악력관위250 mg/(kg·d)；공백대조조우상응시간상동부위주사화관위동등량생리염수。결과A조고골두교B조유교위명현적골세포배사，수강조혈세포활약정도야유명현적감소，A、B조균유골배사후적수복，단B조경위명현。결론해어강개소연합악력치료，대우조기적격소성고골두배사유일정적예방화촉진수복작용。
Objective According to the theory of glucocorticoid-induced avascular necrosis of the osteoporosis, experimental research and treatment of osteoporosis drug salmon calcitonin for glucocorticoid-induced avascular necrosis of the early prevention, and to explore its mechanism. Methods 18 healthy adult SD rats were randomly divided into three groups, Group A:horse serum+dexamethasone;group B:horse serum salmon+dexamethasone+Salmon calcitonin+Compound Calcium Amino Acid Chelate Capsules;C groups:blank control group. A group was injected horse serum 20 ml/(kg?times) by tail vein, twice in total, and interval of 3 weeks between the two injection.Two weeks after the second round of horse serum injection, A group were given gastric lavage with dexamethasone injection for three days, 20 mg/kg?day. In addition to the part same as group A, group B in another horse serum 1 day intramuscular injection salmon calcitonin 10 u/kg?d, and Compound Calcium Amino Acid Chelate Capsules lavage 250 mg/kg?d;Blank control group in the corresponding time same parts injection and gastric same amount of saline solution. Results-Group A‘s femoral head compared with group B has more obvious bone cell necrosis, medullary cavity hematopoietic cells have decreased significantly, the activity of A and B group were osteonecrosis after repair, but group B more clearly. Conclusion Salmon calcitonin Compound Calcium Amino Acid Chelate Capsules, for glucocorticoid-induced avascular necrosis of the early have certain prevention and promote its repair effect.