基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2013年
19期
2477-2478,2479
,共3页
青蒿琥酯%小鼠%脾淋巴细胞%增殖
青蒿琥酯%小鼠%脾淋巴細胞%增殖
청호호지%소서%비림파세포%증식
Artesunate%Mouse%Lymphocyte%Proliferation
目的探讨青蒿琥酯(Artesunate,Art)对小鼠脾淋巴细胞增殖的影响。方法采用四甲基偶氮唑蓝法分别检测 Art 对正常和刀豆蛋白 A 诱导的小鼠脾细胞增殖的影响。结果 Art 对正常增殖的淋巴细胞活性无明显影响;剂量≥12.5μg/mL 时,对刀豆蛋白 A 诱导的淋巴细胞增殖表现出较强的抑制活性(P<0.01),且抑制作用随药物浓度的增加而提高。结论 Art 具有较强的抑制淋巴细胞增殖活性。
目的探討青蒿琥酯(Artesunate,Art)對小鼠脾淋巴細胞增殖的影響。方法採用四甲基偶氮唑藍法分彆檢測 Art 對正常和刀豆蛋白 A 誘導的小鼠脾細胞增殖的影響。結果 Art 對正常增殖的淋巴細胞活性無明顯影響;劑量≥12.5μg/mL 時,對刀豆蛋白 A 誘導的淋巴細胞增殖錶現齣較彊的抑製活性(P<0.01),且抑製作用隨藥物濃度的增加而提高。結論 Art 具有較彊的抑製淋巴細胞增殖活性。
목적탐토청호호지(Artesunate,Art)대소서비림파세포증식적영향。방법채용사갑기우담서람법분별검측 Art 대정상화도두단백 A 유도적소서비세포증식적영향。결과 Art 대정상증식적림파세포활성무명현영향;제량≥12.5μg/mL 시,대도두단백 A 유도적림파세포증식표현출교강적억제활성(P<0.01),차억제작용수약물농도적증가이제고。결론 Art 구유교강적억제림파세포증식활성。
Objective To investigate the effect of artesunate (Art) on spleen lymphocyte proliferation in vitro. Methods Art on the mouse spleen lymphocyte proliferation with or without ConA in vitro were determined by a MTT a ssay. Results Art(≥12.5 μmol/L)significantly inhibited the proliferation of lymphocytes induced by ConA(P < 0.01) while no obvious influences on lymphocyte proliferation were observed in groups without ConA. Conclusion Art showed a good immunoactivity.