CAJ | 학술논문

目的观察盐酸羟考酮治疗老年患者癌痛的临床效果和安全性，为其临床应用提供参考依据。方法将我院2011年12月～2012年12月收治的96例老年晚期癌痛患者随机分为对照组和观察组，每组48例，观察组给予盐酸羟考酮控释片镇痛，对照组给予硫酸吗啡控释片镇痛。治疗8周后，观察和比较两组的镇痛效果和不良反应。结果治疗前，两组VAS评分的差异无统计学意义（P>0.05）；治疗后，两组的VAS评分均较治疗前显著降低（P<0.05），但两组间的差异无统计学意义（P>0.05）。观察组的平均用药量、解救剂量及不良反应发生数均显著低于对照组（P<0.05）。结论盐酸羟考酮控释片用于老年癌痛时的镇痛效果与硫酸吗啡控释片相当，但药物用量和副反应更少，在老年晚期癌痛治疗中具有较高的临床应用价值。
목적관찰염산간고동치료노년환자암통적림상효과화안전성，위기림상응용제공삼고의거。방법장아원2011년12월～2012년12월수치적96례노년만기암통환자수궤분위대조조화관찰조，매조48례，관찰조급여염산간고동공석편진통，대조조급여류산마배공석편진통。치료8주후，관찰화비교량조적진통효과화불량반응。결과치료전，량조VAS평분적차이무통계학의의（P>0.05）；치료후，량조적VAS평분균교치료전현저강저（P<0.05），단량조간적차이무통계학의의（P>0.05）。관찰조적평균용약량、해구제량급불량반응발생수균현저저우대조조（P<0.05）。결론염산간고동공석편용우노년암통시적진통효과여류산마배공석편상당，단약물용량화부반응경소，재노년만기암통치료중구유교고적림상응용개치。
Objective To analyze the clinical effect and safety of Oxycodone Hydrochloride on elderly patients with cancer pain. Methods Ninty-six elderly patients with advanced cancer pain hospitalized between December 2011 and December 2012 were selected and divided into two groups, 48 patients in each group. The observation group was given Oxycodone hydro-chloride retard-20 tablet analgesia, and the control group was treated by Morphine Sulfate Controlled-release Tablets-20 tablet analgesia. After 8 weeks’ treatment, the analgesic effect, medicine dose and adverse reactions were compared between the two groups. Results Before treatment, no significant difference was found in VAS score between the two groups (P>0.05). After 8 weeks’ treatment, the VAS scores of two groups both significantly decreased, but there was no statistically significant difference between the two groups (P>0.05). The average medicine dose, save dose and adverse reactions in the observation group were all evidently less than those of the control group (P<0.05). Conclusion Oxycodone Hydrochloride Controlled-release Tablets had equal analgesic effect as Morphine Sulfate Controlled-release Tablets, but with less dosage and adverse reactions, so it had a better clinical value.