CAJ | 학술논문

目的观察TPF方案与PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效及毒副反应。方法选取63例初诊的局部晚期鼻咽癌患者，随机分为试验组（TPF方案诱导化疗，31例）和对照组（PF方案诱导化疗，32例），诱导化疗2周期后均行同期放化疗，疗程结束后评价两组患者的近期疗效及毒副反应。结果两组的近期疗效比较差异无统计学意义（P=0.519），而试验组粒细胞减少的发生率显著高于对照组（P=0.020）。结论TPF方案与PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效相当，其远期疗效有待于进一步研究。
목적관찰TPF방안여PF방안유도화료연합동기방화료치료국부만기비인암적근기료효급독부반응。방법선취63례초진적국부만기비인암환자，수궤분위시험조（TPF방안유도화료，31례）화대조조（PF방안유도화료，32례），유도화료2주기후균행동기방화료，료정결속후평개량조환자적근기료효급독부반응。결과량조적근기료효비교차이무통계학의의（P=0.519），이시험조립세포감소적발생솔현저고우대조조（P=0.020）。결론TPF방안여PF방안유도화료연합동기방화료치료국부만기비인암적근기료효상당，기원기료효유대우진일보연구。
Objective To compare the short-term efficacy and adverse reactions of TPF or PF neo-adjuvant chemotherapy com-bined with chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Methods Sixty three newly diagnosed locally advanced NPC patients were randomly divided into experimental group (TPF 31 case) and control group (PF 32 case). After two cycles of neo-adjuvant chemotherapy, all the patients underwent concurrent chemoradiotherapy. The short-term efficacy and adverse reaction of both groups were evaluated at the end of treatment. Results There were no significant differences in the short-term efficacy between the two groups (P=0.519). The incidence of neutropenia significantly increased in experimental group, as compared with control group (P=0.020). Conclusion TPF and PF neo-adjuvant chemotherapy combined with chemoradiotherapy had equal short-term clinical efficacy in the treatment of locally advanced nasopharyngeal carcinoma, while the long-term efficacies were still needed to be further researched.