CAJ | 학술논문

目的了解本地区人类免疫缺陷病毒（HIV）阳性女性宫颈人乳头瘤病毒（HPV）感染状况，为HIV阳性人群中HPV感染的防治提供依据。方法采用ELISA法和胶体金法检测4576例女性患者血清或血浆中的HIV抗体，两种方法均为阳性标本再送检确认。PCR+膜杂交法检测病人宫颈脱落细胞及宫颈粘液标本进行HPV病毒基因分型。结果4576例病例中，HIV感染率为0.83%；HPV感染率为21.02%。HIV阳性组中HPV感染率为60.53%，HIV阴性组中HPV感染率20.69%，差异有统计学意义（χ2=36.02，P<0.005）。在962例HPV阳性病例中，HIV阳性组的混合HPV感染率为56.52%；HIV阴性组的混合HPV感染率为20.98%；差异有统计学意义（χ2=16.62，P<0.005）。结论HIV阳性妇女的宫颈HPV感染率高，且高危与多重HPV感染常见，提示HPV感染与HIV感染患者关系密切。
목적료해본지구인류면역결함병독（HIV）양성녀성궁경인유두류병독（HPV）감염상황，위HIV양성인군중HPV감염적방치제공의거。방법채용ELISA법화효체금법검측4576례녀성환자혈청혹혈장중적HIV항체，량충방법균위양성표본재송검학인。PCR+막잡교법검측병인궁경탈락세포급궁경점액표본진행HPV병독기인분형。결과4576례병례중，HIV감염솔위0.83%；HPV감염솔위21.02%。HIV양성조중HPV감염솔위60.53%，HIV음성조중HPV감염솔20.69%，차이유통계학의의（χ2=36.02，P<0.005）。재962례HPV양성병례중，HIV양성조적혼합HPV감염솔위56.52%；HIV음성조적혼합HPV감염솔위20.98%；차이유통계학의의（χ2=16.62，P<0.005）。결론HIV양성부녀적궁경HPV감염솔고，차고위여다중HPV감염상견，제시HPV감염여HIV감염환자관계밀절。
Objective To study the infection of Human papilloma virus (HPV) among HIV-positive women from Hengyang, and to provide a scientific basis for the HPV epidemiological research on HIV-positive groups. Methods A total of 4576 women were tested for sero-antibody of HIV by ELISA and immuno-colloidal golden method. The positive speci-mens detected by both methods were further sent out to confirm. Meanwhile 4576 cervical tissue specimens were examined for HPV by PCR and membrane hybridization method. Results The rate of HIV infection was 0.83% in 4 576 women, and that of HPV was 21.02%. The HPV-positive rate of 60.53% in HIV-positive group had statistical difference from that of 20.69% in HIV-negative group (χ2=36.02, P<0.005). Among 962 HPV-positive women, the rate of mixed HPV infection in HIV-positive group was 56.52%, but that in HIV-negative group was 20.98%; there were statistical difference between the two groups (χ2=16.62, P<0.005). Conclusion The rate of HPV infection of cervix Uteri in HIV-positive women was high, and high risk HPV and multiple HPV infection happened commonly, both of which indicated that HPV infection had close relation with HIV-positive patients.