CAJ | 학술논문

目的探讨基质金属蛋白酶-9（MMP-9）和E-钙粘蛋白（E-cadherin）在乳腺癌中的表达及其临床意义。方法采用免疫组化法检测20例正常乳腺组织、20例乳腺增生组织及50例乳腺癌组织中MMP-9和E-cadherin的表达，并分析两者与乳腺癌的临床病理指标之间的关系。结果MMP-9在正常乳腺、乳腺增生及乳腺癌组织中的阳性表达率分别为5.0％、30.0％、66.0％，在乳腺癌组织中的表达显著高于正常乳腺和乳腺增生组织，而E-cadherin在三组中的阳性表达率则恰好相反，分别为95.0％、85.0％、42.0％，在乳腺癌组织中的表达显著低于正常乳腺和乳腺增生组织，两者在乳腺癌组织中的阳性表达率呈显著负相关（r=-0.605，P<0.05）。MMP-9和E-cadherin的表达均与乳腺癌组织学分级、肿瘤临床TNM分期、腋窝淋巴结转移与否显著相关（P<0.05），而与患者的年龄、肿瘤大小无显著相关性（P>0.05）。结论MMP-9和E-cadherin均与乳腺癌的发生和发展密切相关，且二者在乳腺癌中的表达呈显著负相关，联合检测二者可能对乳腺癌的预后判断更具价值。
목적탐토기질금속단백매-9（MMP-9）화E-개점단백（E-cadherin）재유선암중적표체급기림상의의。방법채용면역조화법검측20례정상유선조직、20례유선증생조직급50례유선암조직중MMP-9화E-cadherin적표체，병분석량자여유선암적림상병리지표지간적관계。결과MMP-9재정상유선、유선증생급유선암조직중적양성표체솔분별위5.0％、30.0％、66.0％，재유선암조직중적표체현저고우정상유선화유선증생조직，이E-cadherin재삼조중적양성표체솔칙흡호상반，분별위95.0％、85.0％、42.0％，재유선암조직중적표체현저저우정상유선화유선증생조직，량자재유선암조직중적양성표체솔정현저부상관（r=-0.605，P<0.05）。MMP-9화E-cadherin적표체균여유선암조직학분급、종류림상TNM분기、액와림파결전이여부현저상관（P<0.05），이여환자적년령、종류대소무현저상관성（P>0.05）。결론MMP-9화E-cadherin균여유선암적발생화발전밀절상관，차이자재유선암중적표체정현저부상관，연합검측이자가능대유선암적예후판단경구개치。
Objective To study the expression and clinical significance of MMP-9 and E-cadherin in breast cancer. Methods 20 cases of normal breast tissue from patients with fiberoadenoma, 20 cases of mammary hyperplasia tissues and 50 cases of breast invasive ductal carcinoma tissues were selected. The expressions of MMP-9 and E-cadherin were detected by immunohisto-chemistry, and the correlation of their expressions with the clinicpathological characteristics of patients with breast cancer was analyzed. Results The positive rate of MMP-9 expression in normal breast, breast hyperplasia and breast cancer tissues was re-spectively 5%, 30%, 66%, which was significantly higher in the breast cancer than in other tissues (P<0.05). Whereas the posi-tive rate of E-cadherin expression in the three groups was respectively 95%, 85%, 42%, which was significantly lower in the breast cancer than that in other tissues (P<0.05). There was a significant negative correlation between the expression of MMP-9 and E-cadherin (r=0.605, P<0.05). Both the expressions of MMP-9 and E-cadherin protein were significantly correlated with the histological grade, tumorous TNM staging and axillary lymph node metastasis of breast cancer (P<0.05), but not related to the age and tumor size (P>0.05). Conclusion Both MMP-9 and E-cadherin played important roles in the development of breast cancer, and their expressions were negatively correlated with each other in breast cancer. Therefore, the combination detection of the two could contribute to the prognosis evaluation of breast cancer.