肿瘤药学
腫瘤藥學
종류약학
ANTI-TUMOR PHARMACY
2013年
3期
166-171
,共6页
胡涂%曾乐平(综述)%黄菊芳(审校)
鬍塗%曾樂平(綜述)%黃菊芳(審校)
호도%증악평(종술)%황국방(심교)
MMP3%TIMP1%基因多态性%肿瘤
MMP3%TIMP1%基因多態性%腫瘤
MMP3%TIMP1%기인다태성%종류
Matrix metalloproteinase 3%Tissue inhibitor of metalloproteinase 1%Gene polymorphism%Tumor
基质金属蛋白酶3（matrix metalloproteinase3, MMP3）是MMPs家族的主要成员之一，其前肽区（propeptide, Pro）和铰链（hinge, H）之间的具有Zn2+活性位点的接触反应性核团（catalytic domain）是其核心反应部位。MMP3在机体内表达的变化和活性的异常参与了多种疾病的病理过程，特别是肿瘤的发生与发展过程。本文将从MMP3的结构、功能、生物化学特性及其在肿瘤发生发展中的作用等方面综述其最新研究进展。
基質金屬蛋白酶3（matrix metalloproteinase3, MMP3）是MMPs傢族的主要成員之一，其前肽區（propeptide, Pro）和鉸鏈（hinge, H）之間的具有Zn2+活性位點的接觸反應性覈糰（catalytic domain）是其覈心反應部位。MMP3在機體內錶達的變化和活性的異常參與瞭多種疾病的病理過程，特彆是腫瘤的髮生與髮展過程。本文將從MMP3的結構、功能、生物化學特性及其在腫瘤髮生髮展中的作用等方麵綜述其最新研究進展。
기질금속단백매3（matrix metalloproteinase3, MMP3）시MMPs가족적주요성원지일，기전태구（propeptide, Pro）화교련（hinge, H）지간적구유Zn2+활성위점적접촉반응성핵단（catalytic domain）시기핵심반응부위。MMP3재궤체내표체적변화화활성적이상삼여료다충질병적병리과정，특별시종류적발생여발전과정。본문장종MMP3적결구、공능、생물화학특성급기재종류발생발전중적작용등방면종술기최신연구진전。
Matrix metalloproteinase 3 (MMP3) is attached to the family of Matrix metalloproteinases (MMPs). And the cata-lytic domain, which is located between the propeptide (Pro) and the hinge and has an active site with Zn2+, is the cardinal active site of MMP3. Its change in gene expression and its abnormal activity contribute to the pathologic processing of many diseases, especially to the development of tumor. This review is aimed at introducing and elaborating MMP3 through its structure, func-tion, biochemistry and its contribution in tumor progression.
