中华普通外科学文献（电子版）
中華普通外科學文獻（電子版）
중화보통외과학문헌（전자판）
CHINESE JOURNAL OF GENERAL SURGERY(ELECTRONIC VERSION)
2013年
3期
197-200
,共4页
冯春在%苏永辉%侯冰宗%李继延%王尧%陈宏
馮春在%囌永輝%侯冰宗%李繼延%王堯%陳宏
풍춘재%소영휘%후빙종%리계연%왕요%진굉
乌司他丁%胃癌%白介素-6%肿瘤坏死因子α
烏司他丁%胃癌%白介素-6%腫瘤壞死因子α
오사타정%위암%백개소-6%종류배사인자α
Ulinastatin%Gastric cancer%Interleukin-6%Tumor necrosis factor-α
目的观察乌司他丁对胃癌术后机体炎症反应的影响。方法选择2011年6月至2012年6月因胃癌行胃癌根治术患者52例，随机双盲分为试验组（28例）和对照组（24例）。试验组在手术当天至术后第3天，每天给予乌司他丁（UTI）1×105 U静脉滴注，每天2次；对照组则以等量生理盐水静脉注射。所有患者在术前1 d及术后1，2，3，6 d空腹抽血检测白介素6（IL-6）、肿瘤坏死因子α（TNF-α）水平和血白细胞（WBC）计数，并进行全身炎症反应综合征（SIRS）评分。结果两组患者术后IL-6、TNF-α、血白细胞水平及SIRS评分在术后1，2，3 d均较术前明显升高（P <0.05），试验组与对照组术后在WBC计数及SIRS评分差异无统计学意义。试验组在术后1，2，3 d血清IL-6、TNF-α水平明显低于对照组（P <0.05）。结论胃癌患者术后存在炎症反应，乌司他丁可降低胃癌患者术后血清IL-6、TNF-α的浓度。
目的觀察烏司他丁對胃癌術後機體炎癥反應的影響。方法選擇2011年6月至2012年6月因胃癌行胃癌根治術患者52例，隨機雙盲分為試驗組（28例）和對照組（24例）。試驗組在手術噹天至術後第3天，每天給予烏司他丁（UTI）1×105 U靜脈滴註，每天2次；對照組則以等量生理鹽水靜脈註射。所有患者在術前1 d及術後1，2，3，6 d空腹抽血檢測白介素6（IL-6）、腫瘤壞死因子α（TNF-α）水平和血白細胞（WBC）計數，併進行全身炎癥反應綜閤徵（SIRS）評分。結果兩組患者術後IL-6、TNF-α、血白細胞水平及SIRS評分在術後1，2，3 d均較術前明顯升高（P <0.05），試驗組與對照組術後在WBC計數及SIRS評分差異無統計學意義。試驗組在術後1，2，3 d血清IL-6、TNF-α水平明顯低于對照組（P <0.05）。結論胃癌患者術後存在炎癥反應，烏司他丁可降低胃癌患者術後血清IL-6、TNF-α的濃度。
목적관찰오사타정대위암술후궤체염증반응적영향。방법선택2011년6월지2012년6월인위암행위암근치술환자52례，수궤쌍맹분위시험조（28례）화대조조（24례）。시험조재수술당천지술후제3천，매천급여오사타정（UTI）1×105 U정맥적주，매천2차；대조조칙이등량생리염수정맥주사。소유환자재술전1 d급술후1，2，3，6 d공복추혈검측백개소6（IL-6）、종류배사인자α（TNF-α）수평화혈백세포（WBC）계수，병진행전신염증반응종합정（SIRS）평분。결과량조환자술후IL-6、TNF-α、혈백세포수평급SIRS평분재술후1，2，3 d균교술전명현승고（P <0.05），시험조여대조조술후재WBC계수급SIRS평분차이무통계학의의。시험조재술후1，2，3 d혈청IL-6、TNF-α수평명현저우대조조（P <0.05）。결론위암환자술후존재염증반응，오사타정가강저위암환자술후혈청IL-6、TNF-α적농도。
Objective To study the effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer. Methods From June 2011 to June 2012, 52 patients underwent radical gastrectomy for gastric cancer were randomized to two groups in double-blind manner:trial group(28 cases) and control group(24 cases). Patients in the trial groups were subjected to intravenous infusion of 100 000 U of Ulinastatin (UTI) twice a day on the postoperative day 0-3,and those in the control group were injected the same volume of saline. The level of interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), white blood cell (WBC) counts in blood samples were measured before surgery and the 1st, 2nd, 3rd, 6th day after surgery. The systemic inflammatory response syndrome (SIRS) score was also commented. Results Postoperative IL-6, TNF-α, WBC counts and SIRS score were significantly higher on the 1st, 2nd and 3rd day after surgery compared with the day before surgery (P <0.05). There was no significant difference after srygery between the trial group and the control group in WBC counts and SIRS score. While the serum IL-6 and TNF-αlevel was significantly lower on the 1st, 2nd and 3rd day after surgery in experimental group compared with the control group (P <0.05). Conclusions Inflammatory response occurs after suygery in Gastric cancer patients. Ulinastatin could inhibit the postoperative serum IL-6, TNF-αconcentration.
