CAJ | 학술논문

核转录因子p53是重要的肿瘤抑制因子，具有DNA损伤修复、促细胞凋亡、促细胞分化及增殖抑制等功能，并通过调控细胞周期行进和促进细胞凋亡发挥肿瘤抑制功能。原癌蛋白MDM2为p53的E3泛素化连接酶，MDM2-p53信号轴的功能异常与多种恶性肿瘤的发生发展相关。核糖体蛋白（RP）是蛋白质合成反应的关键调节蛋白，其功能失常与多种疾病相关。近年来的研究发现，RP能通过调节MDM2-p53信号轴在p53相关性肿瘤调控中发挥重要作用。我们根据目前的研究进展，对RP-MDM2-p53信号轴进行简要综述。
핵전록인자p53시중요적종류억제인자，구유DNA손상수복、촉세포조망、촉세포분화급증식억제등공능，병통과조공세포주기행진화촉진세포조망발휘종류억제공능。원암단백MDM2위p53적E3범소화련접매，MDM2-p53신호축적공능이상여다충악성종류적발생발전상관。핵당체단백（RP）시단백질합성반응적관건조절단백，기공능실상여다충질병상관。근년래적연구발현，RP능통과조절MDM2-p53신호축재p53상관성종류조공중발휘중요작용。아문근거목전적연구진전，대RP-MDM2-p53신호축진행간요종술。
As an important tumor suppressor, p53 plays an essential role in maintaining cell homeostasis and preventing tumourigenesis by inducing DNA repair, apoptosis, cell division and growth suppression. Oncoprotein MDM2 functions as one of the E3 ubiquitin ligases of p53 and the abnormality in MDM2-p53 signaling cascade contributes largely to tumor initiation and progression. It's recently reported that ribosomal proteins(RP), the key players in protein synthesis, exerts a role in modulating MDM2-p53 pathway and therefore functions as a novel regulator in p53-related cancers. Here we summarized the recent data regarding the RP-MDM2-p53 pathway.