CAJ | 학술논문

增食欲素作为一种调节进食与能量代谢等生理功能的重要中枢神经肽,与多种神经递质构成中枢调控网络,促进进食,抑制胃肠蠕动,增强胃酸分泌.增食欲素对机体自发运动有向上调节作用,且比促食作用更明显,从而增加机体非运动活动产热,影响休息/非休息能量消耗比.此外增食欲素还能提高褐色脂肪组织的生热作用,共同增强机体能量消耗,干预肥胖发展.
증식욕소작위일충조절진식여능량대사등생리공능적중요중추신경태,여다충신경체질구성중추조공망락,촉진진식,억제위장연동,증강위산분비.증식욕소대궤체자발운동유향상조절작용,차비촉식작용경명현,종이증가궤체비운동활동산열,영향휴식/비휴식능량소모비.차외증식욕소환능제고갈색지방조직적생열작용,공동증강궤체능량소모,간예비반발전.
Orexin,a significant central neuropeptide,homeostatically coordinates multiple physiological functions,including feeding behavior and energy metabolism.In the context of a brain regulation network,orexin plays a key role in increasing food intake,inhibiting gastrointestinal motility and promoting the secretion of gastric acid,working with several kinds of neurotransmitters.The elevated orexin may result in the increase of spontaneous physical activity,which is greater than orexigenic effects.The greater activation of orexin-induced spontaneous physical activity may raise nonexercise activity thermogenesis and affect the resting/non-resting energy expenditure ratio.Orexin may enhance brown adipose tissue thermogenesis energy expenditure,therefore intervene the development of obesity.