中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2013年
5期
575-577
,共3页
Vogt-小柳-原田病%曲安奈德%糖皮质激素%Tenon囊
Vogt-小柳-原田病%麯安奈德%糖皮質激素%Tenon囊
Vogt-소류-원전병%곡안내덕%당피질격소%Tenon낭
VVogt-Koyanagi-Harada disease%Triamcinolone acetonide%Pmethylprednisolone%Tenon' s capsula
目的 观察曲安奈德(TA)球筋膜下(Tenon囊)注射联合全身糖皮质激素治疗Vogt-小柳-原田氏病(VKH)的浆液性视网膜脱离的效果.方法 于2010年5月至2011年10月在眼科门诊就诊的Vogt-小柳-原田病患者23例46只眼,随机分为两组,对照组(22只眼)单纯给予糖皮质激素治疗；观察组(24只眼)糖皮质激素联合曲安奈德球筋膜下注射治疗.两组患者分别在治疗前及治疗后1周、1个月、3个月、6个月常规检查裸眼视力、最佳矫正视力、眼前节检查、眼底荧光血管造影(FFA)和光学相干断层扫描(OCT)检查,并对数据进行分析.结果 治疗后不同时期,观察组视力提高水平均较对照组高；治疗3个月后两组患者荧光血管造影图像的比较,观察组有效率(91.6％)高于对照组(63.6％),差异有统计学意义(x2=5.3008,P=0.021).治疗后黄斑区视网膜神经上皮层的厚度,观察组为(151±53) μm,对照组为(283±67) μm,两组差别有统计学意义(P =0.000).患者视力和视网膜神经上皮层厚度进行相关性分析(r=-0.897,P=0.000)；视力水平和神经上皮层厚度呈显著负相关.结论 全身大剂量糖皮质激素联合曲安奈德球筋膜下注射可以促进黄斑区视网膜下积液迅速吸收,恢复视功能,缩短治疗时间.
目的 觀察麯安奈德(TA)毬觔膜下(Tenon囊)註射聯閤全身糖皮質激素治療Vogt-小柳-原田氏病(VKH)的漿液性視網膜脫離的效果.方法 于2010年5月至2011年10月在眼科門診就診的Vogt-小柳-原田病患者23例46隻眼,隨機分為兩組,對照組(22隻眼)單純給予糖皮質激素治療；觀察組(24隻眼)糖皮質激素聯閤麯安奈德毬觔膜下註射治療.兩組患者分彆在治療前及治療後1週、1箇月、3箇月、6箇月常規檢查裸眼視力、最佳矯正視力、眼前節檢查、眼底熒光血管造影(FFA)和光學相榦斷層掃描(OCT)檢查,併對數據進行分析.結果 治療後不同時期,觀察組視力提高水平均較對照組高；治療3箇月後兩組患者熒光血管造影圖像的比較,觀察組有效率(91.6％)高于對照組(63.6％),差異有統計學意義(x2=5.3008,P=0.021).治療後黃斑區視網膜神經上皮層的厚度,觀察組為(151±53) μm,對照組為(283±67) μm,兩組差彆有統計學意義(P =0.000).患者視力和視網膜神經上皮層厚度進行相關性分析(r=-0.897,P=0.000)；視力水平和神經上皮層厚度呈顯著負相關.結論 全身大劑量糖皮質激素聯閤麯安奈德毬觔膜下註射可以促進黃斑區視網膜下積液迅速吸收,恢複視功能,縮短治療時間.
목적 관찰곡안내덕(TA)구근막하(Tenon낭)주사연합전신당피질격소치료Vogt-소류-원전씨병(VKH)적장액성시망막탈리적효과.방법 우2010년5월지2011년10월재안과문진취진적Vogt-소류-원전병환자23례46지안,수궤분위량조,대조조(22지안)단순급여당피질격소치료；관찰조(24지안)당피질격소연합곡안내덕구근막하주사치료.량조환자분별재치료전급치료후1주、1개월、3개월、6개월상규검사라안시력、최가교정시력、안전절검사、안저형광혈관조영(FFA)화광학상간단층소묘(OCT)검사,병대수거진행분석.결과 치료후불동시기,관찰조시력제고수평균교대조조고；치료3개월후량조환자형광혈관조영도상적비교,관찰조유효솔(91.6％)고우대조조(63.6％),차이유통계학의의(x2=5.3008,P=0.021).치료후황반구시망막신경상피층적후도,관찰조위(151±53) μm,대조조위(283±67) μm,량조차별유통계학의의(P =0.000).환자시력화시망막신경상피층후도진행상관성분석(r=-0.897,P=0.000)；시력수평화신경상피층후도정현저부상관.결론 전신대제량당피질격소연합곡안내덕구근막하주사가이촉진황반구시망막하적액신속흡수,회복시공능,축단치료시간.
Objective To observe the clinic effect of Vogt-Koyanagi-Harada (VKH) disease by injecting triamcinolone acetonide (TA) under Tenon' s.Methods Forty-six eyes of 23 consecutive patients diagnosed with diagnosed with acute VKH disease in our department of ophthalmology from May 2010 to October 2011.All the patients were divided into 2 groups:control group (22 eyes) were given pmethylprednisolone and observed group (24 eyes) were given pmethylprednisolone combined with TA injection under Tenon' s.All the patients were performed no-corrected visual activity,best corrected visual activity,slit-lamp check,fundus photograph and spectral-domain optical coherence tomography (OCT) at the initial visit and 1 week,1 month,3 months,and 6 months after steroid treatment.All the data were analyzed by SPSS 13.0.Results After the treatment,the VA improved levels was higher in observed group than in control group.After treatment 3 months,the FFA of VKH disease showed the effective was higher in observed group (91.6％) than in control group (63.6％),there was significantly difference between the two groups (x2=5.3008,P =0.021).The thickness of fovea was (151±53)μm in observed group and (283±67)μm in control group,there was significantly difference between the two groups (P =000).There was statistically significant correlation between the vision activity with the thickness of serous retinal detachment (r =-0.897,P =0.000).Conclusions The patients with VHK disease treated by pmethylprednisolone combined with TA injection under Tenon's can enhance the clinic effect and reduce the treatment time.
