中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
z1期
133-136
,共4页
宫颈癌%Meta分析%影响因素
宮頸癌%Meta分析%影響因素
궁경암%Meta분석%영향인소
Cervical cancer%Meta-analysis%Comprehensive analysis
目的 探讨近10年中国已婚妇女宫颈癌发生的影响因素,为预防和控制宫颈癌的发病提供循证依据.方法 以“宫颈癌”、“危险因素”、“影响因素”和“病例对照研究”为检索词,收集2002-2011年关于中国已婚妇女宫颈癌发病有关的研究,应用Meta分析的Mantl-Haensel固定效应模型及Dersimonion-Laird随机效应模型,综合定量评价宫颈癌危险因素的作用.结果 纳入本次Meta分析的研究文献共8篇,累计宫颈癌病例2868例,对照8045例.宫颈癌的影响因素分别为人类乳头瘤病毒(HPV)感染(RR =5.47,95％CI 3.40 ～8.82)、肿瘤家族史(RR =2.40,95％ CI 1.39～4.16)、多产(RR=1.74,95％ CI 1.49～2.03)、初次性交年龄过小(RR=1.72,95％ CI 1.36～2.16)和文化程度较低(RR=1.68,95％ CI 1.18～2.40).结论 影响中国已婚妇女宫颈癌发生的主要危险因素是HPV感染、肿瘤家族史、多产、初次性交年龄过小和文化程度较低.
目的 探討近10年中國已婚婦女宮頸癌髮生的影響因素,為預防和控製宮頸癌的髮病提供循證依據.方法 以“宮頸癌”、“危險因素”、“影響因素”和“病例對照研究”為檢索詞,收集2002-2011年關于中國已婚婦女宮頸癌髮病有關的研究,應用Meta分析的Mantl-Haensel固定效應模型及Dersimonion-Laird隨機效應模型,綜閤定量評價宮頸癌危險因素的作用.結果 納入本次Meta分析的研究文獻共8篇,纍計宮頸癌病例2868例,對照8045例.宮頸癌的影響因素分彆為人類乳頭瘤病毒(HPV)感染(RR =5.47,95％CI 3.40 ～8.82)、腫瘤傢族史(RR =2.40,95％ CI 1.39～4.16)、多產(RR=1.74,95％ CI 1.49～2.03)、初次性交年齡過小(RR=1.72,95％ CI 1.36～2.16)和文化程度較低(RR=1.68,95％ CI 1.18～2.40).結論 影響中國已婚婦女宮頸癌髮生的主要危險因素是HPV感染、腫瘤傢族史、多產、初次性交年齡過小和文化程度較低.
목적 탐토근10년중국이혼부녀궁경암발생적영향인소,위예방화공제궁경암적발병제공순증의거.방법 이“궁경암”、“위험인소”、“영향인소”화“병례대조연구”위검색사,수집2002-2011년관우중국이혼부녀궁경암발병유관적연구,응용Meta분석적Mantl-Haensel고정효응모형급Dersimonion-Laird수궤효응모형,종합정량평개궁경암위험인소적작용.결과 납입본차Meta분석적연구문헌공8편,루계궁경암병례2868례,대조8045례.궁경암적영향인소분별위인류유두류병독(HPV)감염(RR =5.47,95％CI 3.40 ～8.82)、종류가족사(RR =2.40,95％ CI 1.39～4.16)、다산(RR=1.74,95％ CI 1.49～2.03)、초차성교년령과소(RR=1.72,95％ CI 1.36～2.16)화문화정도교저(RR=1.68,95％ CI 1.18～2.40).결론 영향중국이혼부녀궁경암발생적주요위험인소시HPV감염、종류가족사、다산、초차성교년령과소화문화정도교저.
Objective To investigate the risk factors of cervical cancer in Chinese married women in recent 10 years in order to provide evidence based approaches for cervical cancer prevention and control Methods Eight case-control studies from 2002 to 2011 were selected from research literatures by using keywords such as "cervical cancer"," risk factors"," influential factors" and "case-control study"," cancer"," risk factors"," factors" and " case-control study" as the search term.We adopted the Mentel-Haensel fixed effect model and Dersimonion-Laird random effect model to gain a comprehensive and quantitative assessment of cervical cancer and its risk factors.Results Among the 8 case-control studies,the total number of cases and controls were 2868 and 8045,respectively.The risk factors included human papilloma virus (HPV) (RR =5.47,95 ％ CI:3.40-8.82),family history of cervical cancer (RR =2.40,95 ％ CI:1.39-4.16),number of abortions (RR =1.74,95％ CI:1.49-2.03),first sexual intercourse age number of sexual partners (1.72,95％ CI:1.36-2.16),low cultural level (RR =1.68,95％ CI:1.18-2.40).Conclusion The major risk factors for cervical cancer among married women in China included HPV,family history of cervical cancer,number of abortions,first sexual intercourse age number of sexual partners and low cultural level.
