CAJ | 학술논문

目的幽门螺杆菌（Helicobacter pylori，Hp）耐药率逐渐增加，标准四联疗法根除率下降，需要新的治疗方法。方法78例患者随机分成治疗组和对照组，治疗组（序贯疗法）方案为前5d 雷贝拉唑+阿莫西林，后5d 雷贝拉唑+左氧氟沙星+替硝唑，疗程共10d。对照组（标准四联疗法）方案为雷贝拉唑+阿莫西林+克拉霉素+果胶铋，疗程共10d。所有患者停药4周后复查14C 尿素呼气试验检测HP 根除率。结果序贯治疗（治疗组）Hp 根除率84.6%（33/39），四联疗法（对照组）Hp 根除率为71.8%（28/39），两组间比较差异有统计学意义（P ＜0.05）。结论10d 序贯疗法 Hp 根除率优于标准四联疗法。
목적유문라간균（Helicobacter pylori，Hp）내약솔축점증가，표준사련요법근제솔하강，수요신적치료방법。방법78례환자수궤분성치료조화대조조，치료조（서관요법）방안위전5d 뢰패랍서+아막서림，후5d 뢰패랍서+좌양불사성+체초서，료정공10d。대조조（표준사련요법）방안위뢰패랍서+아막서림+극랍매소+과효필，료정공10d。소유환자정약4주후복사14C 뇨소호기시험검측HP 근제솔。결과서관치료（치료조）Hp 근제솔84.6%（33/39），사련요법（대조조）Hp 근제솔위71.8%（28/39），량조간비교차이유통계학의의（P ＜0.05）。결론10d 서관요법 Hp 근제솔우우표준사련요법。
Objective Antibiotics resistance of Helicobacter pylori(HP) increased, eradication rate of conventional quadruple therapy decreased gradually.New fist-line treatments for Hp eradication need to be developed.Methods We have prospectively evaluated 10-day sequential therapy versus conventional quadruple therapy in HP eradication rate.Seventy-eight patients with HP infection were prospectively randomized to receive 5 days of rabeprazole and amoxicillin followed 5 dqys of rabeprazole, Levofloxacin and Tinidazole(sequential-therapy) or 10-days rabeprazole, amoxicillin, clarithromycin and bismuth(conventional quadruple therapy).HP was detected by the 14C-urea breath test at the fourth week post-treatment.Results HP eradication rates were 84.6% in the sequential therapy group and 71.8% in the conventional quadruple therapy group.The difference between the sequential therapy group and the conventional quadruple therapy group was significant(P<0.05).Conclusions 10-day sequential therapy yielded a higher HP eradication rate than 10-day conventional quadruple therapy .