CAJ | 학술논문

目的探讨 Th17细胞调控哮喘患者体内炎性反应的机制。方法以10例哮喘患者和10例健康志愿者为研究对象，分别留取外周血标本。利用流式细胞仪检测外周血中 Th17细胞的比例，ELISA 法检测血浆中 IL-17的水平。结果 Th17细胞在哮喘组的比例（28.53±7.20）%高于对照组（14.72±2.33）%，有统计学差异（P ＜0.01）。IL-17在哮喘组的浓度（102.31±11.45）pg/mL 明显高于对照组（59.68±8.85） pg/mL，P ＜0.01。结论 Th17细胞与哮喘具有相关性，可能通过分泌以 IL-17为主的细胞因子来上调炎性反应，加重哮喘病情。
목적탐토 Th17세포조공효천환자체내염성반응적궤제。방법이10례효천환자화10례건강지원자위연구대상，분별류취외주혈표본。이용류식세포의검측외주혈중 Th17세포적비례，ELISA 법검측혈장중 IL-17적수평。결과 Th17세포재효천조적비례（28.53±7.20）%고우대조조（14.72±2.33）%，유통계학차이（P ＜0.01）。IL-17재효천조적농도（102.31±11.45）pg/mL 명현고우대조조（59.68±8.85） pg/mL，P ＜0.01。결론 Th17세포여효천구유상관성，가능통과분비이 IL-17위주적세포인자래상조염성반응，가중효천병정。
Objective To investigate the mechanism of inflammatory reaction regulated by Th17 cells in asthmatic subjects. Methods Peripheral blood was abtained from 10 subjects with asthma and 10 control subjects. Percentage of Th17 cell was detected by FCM, IL-17 in plasma was examined by ELISA. Results Proportion of Th17 cell of asthma group (28.53±7.20)% is significantly higher than that of control group (14.72±2.33)%, P<0.01, to compared with IL-17 level of control group(59.68±8.85)pg/mL, there was significant increase in asthma group(102.31±11.45)pg/mL, P<0.01. Conclusions The results demonstrated that Th17 cell is associated with asthma, and probably promotes the disturbance of inflammatory reaction by secreting IL-17.