CAJ | 학술논문

目的探讨 D-二聚体在重症急性胰腺炎时的变化。方法共检测收入本院的126例患者，其中38例重症急性胰腺炎患者及88例轻症急性胰腺炎患者，160名健康体检者作为对照，测定血浆 D-二聚体。记录患者入院后第1天各项实验室指标、48hRanson和24hAPACHE Ⅱ评分，了解 D-二聚体含量与各项实验室指标、评分是否存在相关性。结果 D-二聚体对照组分别为（0.41±0.02） mg/L，轻症急性胰腺炎组为（0.74±0.14）mg/L，二者差异均统计学意义（P ＜0.05），重症急性胰腺炎组为（2.69±0.63）mg/L，与对照组及轻症急性胰腺炎组比较差异均有统计学意义（P ＜0.05）。AP 患者血浆 D-二聚体水平与48h Ranson 评分、24h APACHEⅡ评分均呈显著正相关（r 值分别为0.739和0.705，P ＜0.01）结论 AP 患者血浆 D-二聚体升高，D-二聚体含量和胰腺炎病情严重程度明显相关。
목적탐토 D-이취체재중증급성이선염시적변화。방법공검측수입본원적126례환자，기중38례중증급성이선염환자급88례경증급성이선염환자，160명건강체검자작위대조，측정혈장 D-이취체。기록환자입원후제1천각항실험실지표、48hRanson화24hAPACHE Ⅱ평분，료해 D-이취체함량여각항실험실지표、평분시부존재상관성。결과 D-이취체대조조분별위（0.41±0.02） mg/L，경증급성이선염조위（0.74±0.14）mg/L，이자차이균통계학의의（P ＜0.05），중증급성이선염조위（2.69±0.63）mg/L，여대조조급경증급성이선염조비교차이균유통계학의의（P ＜0.05）。AP 환자혈장 D-이취체수평여48h Ranson 평분、24h APACHEⅡ평분균정현저정상관（r 치분별위0.739화0.705，P ＜0.01）결론 AP 환자혈장 D-이취체승고，D-이취체함량화이선염병정엄중정도명현상관。
Objective To explore the clinical value of the concentration of plasma D-dimer in patients with severe acute pancreatitis. Methods Plasma concentration of the D-dimer was measured in 88 patients with mild acute pancreatitis(MAP), 38 patients with severe acute pancreatitis (SAP)and 160 normal people as the control group. The results of routine laboratory tests, 48hRanson and 24h APACHEⅡ scores were all recorded. We attempted to find a relationship between the D-dimer level and the results of 48hRanson scores, 24h APACHE scores Ⅱ. Results Compared with the control group, plasma concentration of the D-dimer was much higher in MAP(P<0.05)and SAP patients(P<0.05). The D-dimer level in the SAP group was higher than the MAP group(P<0.05). The rise in the D-dimer level was directly related to the 48h Ranson and 24h APACHE scoresⅡ(r=0.739 and 0.705, P<0.01). Conclusion Plasma concentration of the D-dimer rises in AP patients, the D-dimer level is related to the disease severity.