CAJ | 학술논문

目的观察4种核苷(酸)类似物治疗失代偿期乙肝肝硬化的安全性及有效性。方法回顾性分析我院收治的54例接受及未接受核苷(酸)类似物治疗的失代偿期乙肝肝硬化的患者的临床资料。结果随访期间对照组患者的HBV DNA、ALT、AST、ALB、TBIL、CHE、INR、Child-Pugh评分、MELD评分在4种核苷（酸）类似物治疗前后改善程度方面的差异没有统计学意义（P＞0.05）；观察组患者的HBV DNA、ALT、ALB、CHE、INR、Child-Pugh评分在治疗前后改善程度方面的差异具有显著的统计学意义（P＜0.05），而AST、TBIL、MELD评分在治疗前后改善程度方面的差异没有统计学意义（P＞0.05）。结论4种核苷（酸）类似物治疗失代偿期乙肝肝硬化具有较好的安全性和有效性，值得在临床广为推广。
목적관찰4충핵감(산)유사물치료실대상기을간간경화적안전성급유효성。방법회고성분석아원수치적54례접수급미접수핵감(산)유사물치료적실대상기을간간경화적환자적림상자료。결과수방기간대조조환자적HBV DNA、ALT、AST、ALB、TBIL、CHE、INR、Child-Pugh평분、MELD평분재4충핵감（산）유사물치료전후개선정도방면적차이몰유통계학의의（P＞0.05）；관찰조환자적HBV DNA、ALT、ALB、CHE、INR、Child-Pugh평분재치료전후개선정도방면적차이구유현저적통계학의의（P＜0.05），이AST、TBIL、MELD평분재치료전후개선정도방면적차이몰유통계학의의（P＞0.05）。결론4충핵감（산）유사물치료실대상기을간간경화구유교호적안전성화유효성，치득재림상엄위추엄。
Objective To observe the safety and efficacy of four nucleosides (acid) analogues in the treatment of decompensated hepatitis B cirrhosis. Methods Retrospectively analyzed the clinical data of the 54 cases of patients with decompensated cirrhosis who accepted or not accepted nucleos (t) ide analogue therapy in our hospital. Results During follow-up, the differences of improve degree of the control group patients’ HBV DNA, ALT, AST, ALB, TBIL, CHE, INR, Child-Pugh score, MELD score before and after the four nucleoside (acid) analogues treatment were not statistically significant(P>0.05);The differences of improve degree of the observation group patients’ HBV DNA, ALT, ALB, CHE, INR, Child-Pugh score before and after treatment were statistically significant (P<0.05) significantly;while AST, TBIL MELD score were not statistically significant (P>0.05). Conclusion Four nucleosides (acid) analogues are safe and efficient in the treatment of decompensated hepatitis B cirrhosis, they deserve to be widely promoted in the clinical.