中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
15期
34-35
,共2页
奈达铂%增敏放疗%单纯放疗%食管癌%中晚期食管癌
奈達鉑%增敏放療%單純放療%食管癌%中晚期食管癌
내체박%증민방료%단순방료%식관암%중만기식관암
Nedaplatin%Sensitizing radiotherapy%Radiotherapy%Esophageal carcinoma%Advanced esophageal cancer
目的分析奈达铂增敏放疗治疗食管癌的疗效和毒副反应，评价奈达铂增敏放疗在食管癌患者中的应用价值。方法将我院收治50例食管癌患者随机分为实验组和对照组，两组患者均不符合手术治疗指征，实验组25例给予奈达铂40mg/w静注，持续6周，同时给予放射治疗；对照组25例患者单纯给予放射治疗，6MX-X射线或15MV-X射线治疗。6周治疗结束后，比较两组患者的治疗效果差异和毒副作用差别。结果实验组近期治疗有效率为76.0%，对照组近期治疗有效率为56.0%，两组患者治疗效果差别显著（P＜0.05），具有统计学意义。放射治疗的毒副反应主要为骨髓移植和食管炎，实验组发生毒副反应人数高于实验组，但可以通过其他处理降低毒副反应发生率。结论食管癌患者单纯放疗效果不佳，周剂量的奈达铂给提高放疗效果，同时给予针对并发症的对症处理能很好降低毒副反应发生率，效果肯定。
目的分析奈達鉑增敏放療治療食管癌的療效和毒副反應，評價奈達鉑增敏放療在食管癌患者中的應用價值。方法將我院收治50例食管癌患者隨機分為實驗組和對照組，兩組患者均不符閤手術治療指徵，實驗組25例給予奈達鉑40mg/w靜註，持續6週，同時給予放射治療；對照組25例患者單純給予放射治療，6MX-X射線或15MV-X射線治療。6週治療結束後，比較兩組患者的治療效果差異和毒副作用差彆。結果實驗組近期治療有效率為76.0%，對照組近期治療有效率為56.0%，兩組患者治療效果差彆顯著（P＜0.05），具有統計學意義。放射治療的毒副反應主要為骨髓移植和食管炎，實驗組髮生毒副反應人數高于實驗組，但可以通過其他處理降低毒副反應髮生率。結論食管癌患者單純放療效果不佳，週劑量的奈達鉑給提高放療效果，同時給予針對併髮癥的對癥處理能很好降低毒副反應髮生率，效果肯定。
목적분석내체박증민방료치료식관암적료효화독부반응，평개내체박증민방료재식관암환자중적응용개치。방법장아원수치50례식관암환자수궤분위실험조화대조조，량조환자균불부합수술치료지정，실험조25례급여내체박40mg/w정주，지속6주，동시급여방사치료；대조조25례환자단순급여방사치료，6MX-X사선혹15MV-X사선치료。6주치료결속후，비교량조환자적치료효과차이화독부작용차별。결과실험조근기치료유효솔위76.0%，대조조근기치료유효솔위56.0%，량조환자치료효과차별현저（P＜0.05），구유통계학의의。방사치료적독부반응주요위골수이식화식관염，실험조발생독부반응인수고우실험조，단가이통과기타처리강저독부반응발생솔。결론식관암환자단순방료효과불가，주제량적내체박급제고방료효과，동시급여침대병발증적대증처리능흔호강저독부반응발생솔，효과긍정。
Objective?Efficacy and toxicity of nedaplatin sensitizing radiotherapy for esophageal cancer, to evaluate the clinical value of nedaplatin sensitizing radiotherapy in patients with esophageal cancer. Methods 50 patients with esophageal carcinoma were randomly divided into experimental group and control group, two groups of patients were not in conformity with the operation indications for treatment,25 cases in experimental group were given intravenous nedaplatin 40mg\/w, continued for 6 weeks, while giving the radiation therapy;the control group of 25 patients treated with radiotherapy, 6MX-X ray or 15MV-X ray therapy. After 6 weeks of treatment, compare the difference between the two groups in the therapeutic effect and side effects of difference. Results In the experimental group, the effective rate of treatment group was 76%,the effective rate of treatment was 56%,the effect of two groups were significant difference(P<0.05), with statistical significance. The main side effects of radiotherapy for bone marrow transplantation and esophagitis,the experimental group had the number of adverse reaction than that in the experiment group,but can reduce the adverse reaction rates by other treatment. Conclusion Patients with esophageal cancer radiotherapy effect is poor, nedaplatin weekly doses to improve effect of radiotherapy, while giving the complications of symptomatic treatment can reduce the incidence of side effects,efficacy.
