CAJ | 학술논문

目的观察四物汤对维持性血液透析(maintenance hemodialysis，MHD)患者微炎症状态的影响。方法选择符合入选标准的初诊血液透析患者40例，随机分为2组，即促红细胞生成素（Erythropoietin，EPO）组、四物汤与EPO组，分别以EPO、四物汤联合EPO进行治疗，在治疗第6、12周时检测患者血红蛋(hemoglobin，Hb)、C反应蛋白(C-reactie protein，CRP)和血清白细胞介素6（IL-6）的水平。结果四物汤与EPO组治疗第6、12周时血清CRP、IL-6水平较治疗前及EPO组明显降低（P＜0.05，P＜0.01），且第12周降低更为明显。尽管两组Hb皆有显著性提高（P＜0.05，P＜0.01），但以四物汤与EPO治疗组效果更为显著。结论四物汤能改善MHD患者微炎症状态，增加MHD患者EPO的疗效。
목적관찰사물탕대유지성혈액투석(maintenance hemodialysis，MHD)환자미염증상태적영향。방법선택부합입선표준적초진혈액투석환자40례，수궤분위2조，즉촉홍세포생성소（Erythropoietin，EPO）조、사물탕여EPO조，분별이EPO、사물탕연합EPO진행치료，재치료제6、12주시검측환자혈홍단(hemoglobin，Hb)、C반응단백(C-reactie protein，CRP)화혈청백세포개소6（IL-6）적수평。결과사물탕여EPO조치료제6、12주시혈청CRP、IL-6수평교치료전급EPO조명현강저（P＜0.05，P＜0.01），차제12주강저경위명현。진관량조Hb개유현저성제고（P＜0.05，P＜0.01），단이사물탕여EPO치료조효과경위현저。결론사물탕능개선MHD환자미염증상태，증가MHD환자EPO적료효。
Objective?To observe effect of Si-Wu Decoction on microinflammation status in maintenance hemodialysis patients. Methods 40 maintenance hemodialysis patients were divided randomly into two groups, EPO groups and Si-Wu Decoction plus EPO groups, and were treated respectively. Their hemoglobin(Hb), C-reactive protein(CRP), interleukin-6(IL-6)were measured after 6-week and 12-week treatment. Results The level of CRP and IL-6 was lower significantly in Si-Wu Decoction plus EPO group compared to EPO Groups after 6-week treatment(P<0.05, P<0.01),but was more obvious after 12-week treatment. Two groups’ Hb was higher significantly than that of pretherapy(P<0.05, P<0.01), but was more obvious in Si-Wu Decoction plus EPO group. Conclusion Si-Wu Decoction can attenuate microinflammation status, and improve EPO effect on renal anemia in maintenance hemodialysis patients.