CAJ | 학술논문

目的探讨2型糖尿病重度非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)、早期增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)对视盘周围神经纤维层(Retinal Nerve Fiber Layer,RNFL)损害程度.方法收集已确诊为2型糖尿病的重度NP-DR和早期PDR患者73只眼,进行视力、眼压,裂隙灯、眼底、OCT检查.所有个体按正常眼、重度NPDR、早期PDR分组进行比较.结果重度NPDR和早期PDR组平均RNFL厚度均低于正常对照组,视盘上方、下方、鼻侧象限厚度显著降低,有统计学意义(P＜0.05),颞侧象限较正常对照组差异无统计学意义(P＞0.05).重度NPDR和早期PDR组视盘上方、下方、鼻侧、颞侧象限和平均RNFL厚度差异无统计学意义(P＞0.05).结论重度NPDR或早期PDR患者视盘上方、下方、鼻侧象限RNFL厚度呈下降趋势,且以上方和下方象限最为明显.RNFL厚度可以作为血糖控制下评价视网膜损伤的指标.
목적 탐토2형당뇨병중도비증식성당뇨병시망막병변(non-proliferative diabetic retinopathy,NPDR)、조기증식성당뇨병시망막병변(proliferative diabetic retinopathy,PDR)대시반주위신경섬유층(Retinal Nerve Fiber Layer,RNFL)손해정도.방법 수집이학진위2형당뇨병적중도NP-DR화조기PDR환자73지안,진행시력、안압,렬극등、안저、OCT검사.소유개체안정상안、중도NPDR、조기PDR분조진행비교.결과 중도NPDR화조기PDR조평균RNFL후도균저우정상대조조,시반상방、하방、비측상한후도현저강저,유통계학의의(P＜0.05),섭측상한교정상대조조차이무통계학의의(P＞0.05).중도NPDR화조기PDR조시반상방、하방、비측、섭측상한화평균RNFL후도차이무통계학의의(P＞0.05).결론 중도NPDR혹조기PDR환자시반상방、하방、비측상한RNFL후도정하강추세,차이상방화하방상한최위명현.RNFL후도가이작위혈당공제하평개시망막손상적지표.
Objective To study the RNFL damage in serious NPDR and early PDR pre-in 2 type DM.Methods Forty-two cases (73 eyes) of type 2 DM who suffered serious NPDR or early PDR were collected in this study.The best corrected vision,intraocular pressure,and slit-lamp examination,fundus oculi and FFA,OCT examination were observed.All cases were divided into three groups,as for normal eyes,serious NPDR and early PDR eyes.Results Compared with normal eyes,the peripapillary average RNFL thickness decreased significantly in serious NPDR eyes and early PDR eyes,and especially the superior,inferior and nasal regions of optic disk,and the result had statistically significance difference (P ＜0.05),except the temporal (P ＞0.05).The result of RNFL thickness had no statistically significant difference (P ＞0.05) between serious NPDR and early PDR in superior,inferior,nasal temporal regions and peripapillary average RNFL thickness.Conclusions Compared with healthy,the RNFL thickness of superior,inferior,nasal regions of optic disk is downtrend in serious NPDR and early PDR patient,especially superior and inferior regions is the most significant.RNFL thickness can be used as a blood sugar control retina damage evaluation index.