国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
7期
1209-1211
,共3页
糖尿病视网膜病变%神经纤维层%视功能
糖尿病視網膜病變%神經纖維層%視功能
당뇨병시망막병변%신경섬유층%시공능
diabetic retinopathy%nerve fiber layer%visual function
目的：研究非增生性糖尿病视网膜病变( nonproliferative diabetic retinopathy,NPDR)视乳头旁视网膜神经纤维层(retinal nerve fiber layer,RNFL)的厚度及结构改变,及其与视功能变化的相关性。<br> 方法：选取2011-01/2013-12于本院就诊的NPDR患者中80例80眼为NPDR组,同期在本院就诊的60例60眼无视网膜病变的糖尿病患者作为非糖尿病视网膜病变( non-diabetic retinopathy group,NDR)组,另选取同期在我院进行健康体检的50人作为对照组,对三组研究对象进行RNFL厚度及视觉电生理检查,并对其进行组间比较。<br> 结果：NPDR组的上方、下方、鼻侧、颞侧及平均RNFL厚度分别为91.52±18.52,88.63±21.65,63.62±11.72,60.42±9.13,69.36±12.52μm；NDR组的分别为111.32±21.90,113.57±22.67,74.31±11.74,67.64±12.34,97.31±11.43μm；对照组分别为121.65±21.42,129.32±23.31,82.42±9.28,80.32±8.51,102.54±21.82μm。三组的平均RNFL厚度相比较, NPDR组与NDR组均薄于对照组；各象限间相比较,三组间的上方、下方及颞侧的RNFL厚度存在显著差异(P<0.05),而鼻侧无显著变化(P>0.05)；同时三组的60′P100潜伏期( ms)、60′P100振幅(μV)、15′P100潜伏期(ms)及15′P100振幅(μV)均存在显著差异(P<0.05)。<br> 结论：在非增生期糖尿病视网膜病变的早期即已发生RNFL厚度的改变,以上方、下方及颞侧为主,且与视功能的变化呈显著相关性。
目的：研究非增生性糖尿病視網膜病變( nonproliferative diabetic retinopathy,NPDR)視乳頭徬視網膜神經纖維層(retinal nerve fiber layer,RNFL)的厚度及結構改變,及其與視功能變化的相關性。<br> 方法：選取2011-01/2013-12于本院就診的NPDR患者中80例80眼為NPDR組,同期在本院就診的60例60眼無視網膜病變的糖尿病患者作為非糖尿病視網膜病變( non-diabetic retinopathy group,NDR)組,另選取同期在我院進行健康體檢的50人作為對照組,對三組研究對象進行RNFL厚度及視覺電生理檢查,併對其進行組間比較。<br> 結果：NPDR組的上方、下方、鼻側、顳側及平均RNFL厚度分彆為91.52±18.52,88.63±21.65,63.62±11.72,60.42±9.13,69.36±12.52μm；NDR組的分彆為111.32±21.90,113.57±22.67,74.31±11.74,67.64±12.34,97.31±11.43μm；對照組分彆為121.65±21.42,129.32±23.31,82.42±9.28,80.32±8.51,102.54±21.82μm。三組的平均RNFL厚度相比較, NPDR組與NDR組均薄于對照組；各象限間相比較,三組間的上方、下方及顳側的RNFL厚度存在顯著差異(P<0.05),而鼻側無顯著變化(P>0.05)；同時三組的60′P100潛伏期( ms)、60′P100振幅(μV)、15′P100潛伏期(ms)及15′P100振幅(μV)均存在顯著差異(P<0.05)。<br> 結論：在非增生期糖尿病視網膜病變的早期即已髮生RNFL厚度的改變,以上方、下方及顳側為主,且與視功能的變化呈顯著相關性。
목적：연구비증생성당뇨병시망막병변( nonproliferative diabetic retinopathy,NPDR)시유두방시망막신경섬유층(retinal nerve fiber layer,RNFL)적후도급결구개변,급기여시공능변화적상관성。<br> 방법：선취2011-01/2013-12우본원취진적NPDR환자중80례80안위NPDR조,동기재본원취진적60례60안무시망막병변적당뇨병환자작위비당뇨병시망막병변( non-diabetic retinopathy group,NDR)조,령선취동기재아원진행건강체검적50인작위대조조,대삼조연구대상진행RNFL후도급시각전생리검사,병대기진행조간비교。<br> 결과：NPDR조적상방、하방、비측、섭측급평균RNFL후도분별위91.52±18.52,88.63±21.65,63.62±11.72,60.42±9.13,69.36±12.52μm；NDR조적분별위111.32±21.90,113.57±22.67,74.31±11.74,67.64±12.34,97.31±11.43μm；대조조분별위121.65±21.42,129.32±23.31,82.42±9.28,80.32±8.51,102.54±21.82μm。삼조적평균RNFL후도상비교, NPDR조여NDR조균박우대조조；각상한간상비교,삼조간적상방、하방급섭측적RNFL후도존재현저차이(P<0.05),이비측무현저변화(P>0.05)；동시삼조적60′P100잠복기( ms)、60′P100진폭(μV)、15′P100잠복기(ms)급15′P100진폭(μV)균존재현저차이(P<0.05)。<br> 결론：재비증생기당뇨병시망막병변적조기즉이발생RNFL후도적개변,이상방、하방급섭측위주,차여시공능적변화정현저상관성。
AlM: To study the correlation between and the peripapillary retinal nerve fiber layer ( RNFL ) thickness, structure changes in non-proliferative diabetic retinopathy ( NPDR) and the the changes of visual function <br> METHODS:Eighty cases ( 80 eyes ) of patients with NPDR who were in our hospital from January 2011 to December 2013 as group NPDR, 60 cases of patients ( 60 eyes) without retinopathy who were in the hospital were selected as non-diabetic retinopathy group ( NRD) group, meanwhile, 50 healthy people who had health examination in our hospital as control group. The RNFL thickness and visual electrophysiological testing were performed on the study objects in the three groups, and the results were compared among groups. <br> RESULTS: Group NPDR's above, below, nasal, temporal and average RNFL thickness were 91. 52 ± 18. 52, 88.63±21. 65, 63. 62±11. 72, 60. 42±9. 13, 69. 36±12. 52μm, those of group NPDR were 111. 32 ± 21. 90, 113. 57 ± 22. 67, 74.31±11. 74, 67. 64±12. 34, and 97. 31±11. 43μm,those of group control were 121. 65±21. 42, 129. 32±23. 31, 82. 42±9. 28, 80. 32±8. 51, 102. 54±21. 82μm. To compare of average thickness of RNFL of three groups, groups NPDR and NPD were thinner than that of control group;To compare each quadrant phase, above, below, nasal, the RNFL thickness among three groups had statistical significance (P<0.05), while nasal sides had no obviously changes (P>0. 05);At the same time, 60′P100 latency (MS), 60′P100 amplitude ( V ) , 15′ P100 latency ( MS ) and 15′ P100 amplitude ( V) of three groups had statistical significance (P<0. 05). <br> CONCLUSlON: The changes of RNFL thickness have occurred in the early time of NPDR, and mainly the above, below and temporal , and it has a significant relevance with the changes of visual function.
