CAJ | 학술논문

目的：研究转化生长因子β1(transforming growth factor -β1, TGF-β1)和热休克蛋白47(heat shock protein 47,HSP-47)在翼状胬肉和正常结膜组织表达的差异,从而探讨它们在翼状胬肉发生、发展中的作用,为翼状胬肉的治疗提供新的方向。 　　方法：采用免疫组化方法比较翼状胬肉和正常结膜组织中TGF-β1和HSP-47的表达差异。 　　结果：TGF-β1在翼状胬肉的鳞状上皮细胞中的表达水平明显高于正常结膜组织,在其基质层和内皮层有中等量表达,同时,在翼状胬肉纤维层的炎性细胞和血管内皮细胞中TGF-β1也有明显表达。与此相反,在正常结膜组织中TGF-β1表达较弱。 HSP-47在翼状胬肉的固有层高表达,在上皮细胞表达较弱,在正常结膜组织中则未见明显表达。 　　结论：相比正常结膜组织,TGF-β1和HSP-47均在翼状胬肉组织中有较高水平的表达,因此推测二者在诱导翼状胬肉的发生、发展中起着重要的作用。
목적：연구전화생장인자β1(transforming growth factor -β1, TGF-β1)화열휴극단백47(heat shock protein 47,HSP-47)재익상노육화정상결막조직표체적차이,종이탐토타문재익상노육발생、발전중적작용,위익상노육적치료제공신적방향。 　　방법：채용면역조화방법비교익상노육화정상결막조직중TGF-β1화HSP-47적표체차이。 　　결과：TGF-β1재익상노육적린상상피세포중적표체수평명현고우정상결막조직,재기기질층화내피층유중등량표체,동시,재익상노육섬유층적염성세포화혈관내피세포중TGF-β1야유명현표체。여차상반,재정상결막조직중TGF-β1표체교약。 HSP-47재익상노육적고유층고표체,재상피세포표체교약,재정상결막조직중칙미견명현표체。 　　결론：상비정상결막조직,TGF-β1화HSP-47균재익상노육조직중유교고수평적표체,인차추측이자재유도익상노육적발생、발전중기착중요적작용。
AlM:To investigate the expression transforming growth factor-β1 (TGF-β1) and heat shock protein 47 (HSP-47), in pterygium and normal conjunctiva tissues, in order to study the roles of these cytokines played in the pathogenesis in human pterygium. METHODS:The expression difference of TGF-β1, HSP-47 between human pterygium and normal conjunctive tissues were compared by immuno - histochemistry technique. RESULTS:The positive expression of TGF-β1, HSP-47 was stronger than in normal conjunctive tissues ( P <0. 05), the TGF-β1 expressed in all layers of pterygium, especially in the squamous epithelium, in the inflammation cells and vascular endothelial cells also expressed. The HSP-47 showed higher expressed in the lamina propria layer of pterygium, and weakly expressed in epithelial layer, no obvious expression in normal conjunctive tissues. CONCLUSlON:Over-expression of TGF-β1 and HSP-47 in pterygium compared to the normal conjunctiva tissues may play a critical role during the occurrence, development and invasion of the pterygium.