CAJ | 학술논문

目的：探讨喷昔洛韦联合干扰素α-1 b治疗重症带状疱疹的临床效果及安全性。方法将74例重症带状疱疹患者随机分为两组，各37例。对照组给予喷昔洛韦治疗，观察组在对照组基础上加用干扰素α-1 b治疗，对比两组治疗效果及不良反应等。结果治疗后，观察组疼痛缓解时间、止疱时间、皮损消退时间及50％皮损结痂时间均短于对照组（ P ＜0．01）；治疗15 d后，两组治疗效果差异无统计学意义（ P ＞0．05）；两组用药期间均无严重药物不良反应发生；随访3个月，观察组后遗神经痛（PHN）发生率为9．09％，低于对照组的29．03％（ P ＜0．05）。结论喷昔洛韦联合干扰素α-1b治疗重症带状疱疹安全有效，可缩短病程，减少PHN的发生率。
목적：탐토분석락위연합간우소α-1 b치료중증대상포진적림상효과급안전성。방법장74례중증대상포진환자수궤분위량조，각37례。대조조급여분석락위치료，관찰조재대조조기출상가용간우소α-1 b치료，대비량조치료효과급불량반응등。결과치료후，관찰조동통완해시간、지포시간、피손소퇴시간급50％피손결가시간균단우대조조（ P ＜0．01）；치료15 d후，량조치료효과차이무통계학의의（ P ＞0．05）；량조용약기간균무엄중약물불량반응발생；수방3개월，관찰조후유신경통（PHN）발생솔위9．09％，저우대조조적29．03％（ P ＜0．05）。결론분석락위연합간우소α-1b치료중증대상포진안전유효，가축단병정，감소PHN적발생솔。
Objective To investigate the curative effect and safety of the combination therapy of penciclovir with interferon α-1b in treatment of severe herpes zoster .Methods Seventy-four patients with severe herpes zoster were divided into the observation group ( n =37)and the control group( n =37),and the control group was given penciclovir injection ,and the observation group was given additional interferon α-1b muscle injection,and curative effect of the two groups were observed .Results Pain relief time,blister check time,lesions subsiding time and 50% skin crusting time of the observation group after treatment were significantly shorter than that of the control group( P <0.01).After 15 d of treatment,the curative effect of the two groups showed no statistically significant difference( P >0.05).No serious adverse drug reactions occurred during the medication .The incidence rate of neuralgia (PHN)of the observation group was 9.09%,lower than 29.03%of the control group( P <0.05).Conclusion Penciclovir with interferon α-1b in treatment of severe herpes zoster is safe and effective and can significantly shorten the course of the disease and reduce the incidence rate of PHN.