中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
11期
1161-1163
,共3页
右美托咪定%二异丙酚%冠心病
右美託咪定%二異丙酚%冠心病
우미탁미정%이이병분%관심병
Dexmedtomidine%Propofol%Coronary
目的 比较右美托咪定与异丙酚在冠心病患者非心脏手术中的镇痛效果. 方法 选择2009年9月至2011年9月于我院收治的硬膜外麻醉下择期行上腹部手术的冠心病患者86例,年龄55～76岁,体质量42～60 kg,随机分为右美托咪定组和异丙酚组,每组43例,采用视觉模拟评分法(VAS)检测患者术前、术后4、24、48 h末血清皮质醇、胰岛素和血糖的含量变化来评价两组患者的镇痛效果,并术后进行满意度调查. 结果 术后不同时点VAS镇痛评分和Ramsay镇静评分结果显示,右美托咪定组患者的镇痛镇静效果优于异丙酚组,差异有统计学意义(t=5.368、2.262、7.147、5.881、7.861、4.810,P＜0.05).右美托咪定组患者清皮质醇、胰岛素和血糖浓度在术前及术后各个时间点均低于异丙酚组患者,差异有统计学意义(t=3.076、2.042、4.090,P＜0.05),且93.0％(40/43)的患者对Dex组满意. 结论 右美托咪定用于冠心病患者非心脏手术的镇痛效果优于异丙酚,且安全可行.
目的 比較右美託咪定與異丙酚在冠心病患者非心髒手術中的鎮痛效果. 方法 選擇2009年9月至2011年9月于我院收治的硬膜外痳醉下擇期行上腹部手術的冠心病患者86例,年齡55～76歲,體質量42～60 kg,隨機分為右美託咪定組和異丙酚組,每組43例,採用視覺模擬評分法(VAS)檢測患者術前、術後4、24、48 h末血清皮質醇、胰島素和血糖的含量變化來評價兩組患者的鎮痛效果,併術後進行滿意度調查. 結果 術後不同時點VAS鎮痛評分和Ramsay鎮靜評分結果顯示,右美託咪定組患者的鎮痛鎮靜效果優于異丙酚組,差異有統計學意義(t=5.368、2.262、7.147、5.881、7.861、4.810,P＜0.05).右美託咪定組患者清皮質醇、胰島素和血糖濃度在術前及術後各箇時間點均低于異丙酚組患者,差異有統計學意義(t=3.076、2.042、4.090,P＜0.05),且93.0％(40/43)的患者對Dex組滿意. 結論 右美託咪定用于冠心病患者非心髒手術的鎮痛效果優于異丙酚,且安全可行.
목적 비교우미탁미정여이병분재관심병환자비심장수술중적진통효과. 방법 선택2009년9월지2011년9월우아원수치적경막외마취하택기행상복부수술적관심병환자86례,년령55～76세,체질량42～60 kg,수궤분위우미탁미정조화이병분조,매조43례,채용시각모의평분법(VAS)검측환자술전、술후4、24、48 h말혈청피질순、이도소화혈당적함량변화래평개량조환자적진통효과,병술후진행만의도조사. 결과 술후불동시점VAS진통평분화Ramsay진정평분결과현시,우미탁미정조환자적진통진정효과우우이병분조,차이유통계학의의(t=5.368、2.262、7.147、5.881、7.861、4.810,P＜0.05).우미탁미정조환자청피질순、이도소화혈당농도재술전급술후각개시간점균저우이병분조환자,차이유통계학의의(t=3.076、2.042、4.090,P＜0.05),차93.0％(40/43)적환자대Dex조만의. 결론 우미탁미정용우관심병환자비심장수술적진통효과우우이병분,차안전가행.
Objective To compare the analgesic effect of dexmedetomidine and propofol on patients with coronary heart disease undergoing noncardiac surgery.Methods 86 patients in our hospital from Sep 2009 to Sep 2011 aged 55-76 years weighing 42-60 kg,who were scheduled for epidural anesthesia in routine,were randomly assigned to 2 groups:dexmedtomidine (Dex) group and propofol group (n=43,each).Visual analogue scale/score (VAS) analgesia score and ramsay sedation score were used to observe the analgesic effect after surgery.Serum concentration of cortisol,insulin and glucose were observed and compared between Dex and propofol group before and 4,24,48h after surgery.Patient satisfaction was surveyed.Results The analgesic effect evaluated by VAS and Ramsay scores was better in Dex group than in propofol group at different time after surgery (t=5.368,2.262,7.147,5.881,7.861,4.810,all P＜0.05).Serum concentrations of cortisol,insulin and glucose were lower in Dex group than in propofol group before and 4,24,48 h after surgery (t=3.076,2.042,4.090,all P＜0.05).The satisfaction rate was 93.0％ (40/43) in Dex group.Conclusions Dexmedetomidine has a better analgesic effect than propofol,and it is safe and feasible for patients with coronary heart disease undergoing noncardiac surgery.
