CAJ | 학술논문

目的：对胱抑素C （Cys C ）在临床诊断早期肾功能损伤中的价值进行探讨。方法回顾分析该院2011年6月至2013年6月收治的140例慢性肾功能衰竭患者。采用免疫比浊法对其血清中的Cys C、尿β2-微球蛋白和血清肌酐水平进行检测，并与140例健康者的各项指标进行对比分析。结果2组研究对象的性别、年龄差异无统计学意义（P＞0．05）；肾功能损伤患者血清中Cys C 、尿β2-微球蛋白和血清肌酐水平都显著低于健康者，差异有统计学意义（P＜0．05）；而Cys C水平在患者中的特异性以及灵敏度显著大于尿β2-微球蛋白和血清肌酐，差异有统计学意义（P＜0．05）。结论患者血清中Cys C水平具有很好的特异性以及灵敏度，能够及时、准确地对患者的肾功能损伤进行评估，对早期肾功能损害的诊断具有临床价值。
목적：대광억소C （Cys C ）재림상진단조기신공능손상중적개치진행탐토。방법회고분석해원2011년6월지2013년6월수치적140례만성신공능쇠갈환자。채용면역비탁법대기혈청중적Cys C、뇨β2-미구단백화혈청기항수평진행검측，병여140례건강자적각항지표진행대비분석。결과2조연구대상적성별、년령차이무통계학의의（P＞0．05）；신공능손상환자혈청중Cys C 、뇨β2-미구단백화혈청기항수평도현저저우건강자，차이유통계학의의（P＜0．05）；이Cys C수평재환자중적특이성이급령민도현저대우뇨β2-미구단백화혈청기항，차이유통계학의의（P＜0．05）。결론환자혈청중Cys C수평구유흔호적특이성이급령민도，능구급시、준학지대환자적신공능손상진행평고，대조기신공능손해적진단구유림상개치。
Objective To discuss clinical value of cystatin C (Cys C) in the diagnosis of early renal damage . Methods Retrospective analysis the data of 140 cases of chronic renal failure patients treated in our hospital from 2011 June to 2013 June .Cys C ,urinary β2-microglobulin and creatinine levels in serum were detected ,the indicators of those in early renal damage and healthycontrols were analyzed ,and compared .Results Two groups had no signifi-cant difference in gender ,age(P>0 .05) .The levels of Cys C in serum ,the urineβ2-microglobulin and serum creati in patiens of renal function injury were significantly lower than those of healthy subjects (P<0 .05) .Specificity and sen-sitivity of Cys C were more significant than those of urine β2-microglobulin and serum creatinine(P<0 .05) .Conclu-sion The serum Cys C levels in patients has good specificity and sensitivity ,injury on renal function of patients was evaluated ,timely ,accurateiy by Cys C ,Cys C is of great value in diagnosis of early renal dama .