CAJ | 학술논문

目的：探讨不同类型肝炎患者的各项凝血指标，尤其是血小板指标的病理性变化和功能水平以及其检测对各类型肝炎诊断的临床价值。方法抽取96例肝病患者，依据病理机制及病程分为3组，再同期抽取50例健康者作为健康对照组。测定实验组和健康对照组的血浆凝血酶原时间（PT ）、凝血酶时间（T T ）、部分活化凝血活酶时间（APTT）等各项临床指标，并对检测结果进行统计学处理和分析。结果慢性肝炎、重型肝炎及肝硬化组的4项指标与健康对照组比较差异有统计学意义（P＜0．01）。重型肝炎及肝硬化、慢性肝炎患者PT、TT、APTT 明显延长，而纤维蛋白原（FIB ）水平下降。肝炎患者与健康对照者相比，血小板计数（PL T ）、血小板压积（PC T ）明显下降，平均血小板体积（M PV ）、血小板分布宽度（PDW ）明显升高，差异有统计学意义（ P＜0．01）。结论不同类型肝炎患者的凝血功能均有不同程度的损害，且损害程度与病情进展相关。
목적：탐토불동류형간염환자적각항응혈지표，우기시혈소판지표적병이성변화화공능수평이급기검측대각류형간염진단적림상개치。방법추취96례간병환자，의거병리궤제급병정분위3조，재동기추취50례건강자작위건강대조조。측정실험조화건강대조조적혈장응혈매원시간（PT ）、응혈매시간（T T ）、부분활화응혈활매시간（APTT）등각항림상지표，병대검측결과진행통계학처리화분석。결과만성간염、중형간염급간경화조적4항지표여건강대조조비교차이유통계학의의（P＜0．01）。중형간염급간경화、만성간염환자PT、TT、APTT 명현연장，이섬유단백원（FIB ）수평하강。간염환자여건강대조자상비，혈소판계수（PL T ）、혈소판압적（PC T ）명현하강，평균혈소판체적（M PV ）、혈소판분포관도（PDW ）명현승고，차이유통계학의의（ P＜0．01）。결론불동류형간염환자적응혈공능균유불동정도적손해，차손해정도여병정진전상관。
Objective To explore the various different types of hepatitis coagulation indicators ,especially indi-cators of pathological changes in platelet and functional levels and the detection of various types of hepatitis diagnos-tic value .Methods 96 cases of patients with liver extract ,according to the pathological mechanism and the course is divided into three groups ,and then extracting the same period 50 healthy persons were being control group .In the experimental group and the control group ,prothrombin time(PT) ,thrombin time(TT) ,activated partial thrombo-plastin time(APTT) and other clinical parameters were determinated ,and the test results were statisticed and analy-sised .Results Those four indicators with chronic hepatitis ,severe hepatitis and cirrhosis groups were significantly different ,compared to healthy control group (P<0 .01) .PT ,TT ,APTT in the patients of severe hepatitis and liver cirrhosis ,chronic hepatitis ,were prolonged ,and FIB content decreased .Compared with those in control group ,plate-let count ,platelet hematocrit decreased significantly in hepatitis patients (P<0 .01) ,mean platelet volume ,platelet distribution width was significantly higher (P<0 .01) .Conclusion Different types of blood coagulation function in patients with hepatitis have varying degrees of damage ,and damage associated with disease progression .