CAJ | 학술논문

目的：观察不同程度小儿肺炎时，血清致炎性因子肿瘤坏死因子（TNF-α）、肺表面活性蛋白A（SP-A）表达含量的变化及其临床意义。方法将195例肺炎儿童根据病情严重程度将其分为普通肺炎患儿及重症肺炎患儿，另外选择65例非肺炎患儿作为对照组，采用ELISA方法检测不同程度肺炎血清中的TNF-α和 SP-A 水平。结果 TNF-α、SP-A在普通、重症肺炎患儿血清中表达水平显著升高，且重症肺炎组的TNF-α、SP-A表达水平显著高于普通肺炎组。结论在小儿重症肺炎患儿发病过程中，血清中肿瘤坏死因子TNF-α和肺表面活性蛋白SP-A的表达水平明显增多，可以反映肺损伤程度，可作为临床检测指标。
목적：관찰불동정도소인폐염시，혈청치염성인자종류배사인자（TNF-α）、폐표면활성단백A（SP-A）표체함량적변화급기림상의의。방법장195례폐염인동근거병정엄중정도장기분위보통폐염환인급중증폐염환인，령외선택65례비폐염환인작위대조조，채용ELISA방법검측불동정도폐염혈청중적TNF-α화 SP-A 수평。결과 TNF-α、SP-A재보통、중증폐염환인혈청중표체수평현저승고，차중증폐염조적TNF-α、SP-A표체수평현저고우보통폐염조。결론재소인중증폐염환인발병과정중，혈청중종류배사인자TNF-α화폐표면활성단백SP-A적표체수평명현증다，가이반영폐손상정도，가작위림상검측지표。
Objective To observe the expression levels change and it's clinical significance of TNF-α, SP-A in chil-dren with varying degrees of pneumonia. Methods A total 195 cases of pneumonia children patients were divided into ordinary pneumonia and severe pneumonia patients , another 65 cases of non-pneumonic children patients as the con-trol group, ELISA assay was used to detect serum TNF-α and SP-A level. Results The levels of serum SP-A and TNF-αof pneumonia children group were higher than the control group's , and severe pneumonia patients ’ were high-er than ordinary pneumonia. Conclusion The expression level of TNF-α and SP-A increased significant in the patho-genesis of children with severe pneumonia which could reflect the degree of lung injury and as a indicator in clinical testing.