CAJ | 학술논문

目的：评价早期康复联合注射用血栓通冻干粉治疗急性脑梗死的疗效及对患者血低密度胆固醇（LDL-C ）和超敏C-反应蛋白（hs-CRP）水平的影响。方法将120例急性脑梗死患者随机分为对照组和治疗组，对照组予以常规治疗加生理盐水500mL，治疗组在常规治疗基础上予以早期康复治疗+血栓通针0.5 g，1次/d，连续21 d。采用美国国立卫生研究院卒中量表（NIHSS）评估患者神经功能缺损程度，改良Barthel指数（MBI）评价患者日常生活活动能力。观察治疗前后LDL-C和hs-CRP水平的变化及不良反应。结果与对照组相比，治疗组患者的神经功能缺损明显改善，日常生活活动能力明显改善（P<0.05）。与对照组比较，治疗后两组LDL-C和hs-CRP均明显改善（P<0.05），与对照组相比，治疗组LDL-C和hs-CRP均明显下降（P<0.05）。结论早期康复联合注射用血栓通冻干粉用于治疗急性脑梗死有显著的疗效，并能降低患者LDL-C和hs-CRP水平。
목적：평개조기강복연합주사용혈전통동간분치료급성뇌경사적료효급대환자혈저밀도담고순（LDL-C ）화초민C-반응단백（hs-CRP）수평적영향。방법장120례급성뇌경사환자수궤분위대조조화치료조，대조조여이상규치료가생리염수500mL，치료조재상규치료기출상여이조기강복치료+혈전통침0.5 g，1차/d，련속21 d。채용미국국립위생연구원졸중량표（NIHSS）평고환자신경공능결손정도，개량Barthel지수（MBI）평개환자일상생활활동능력。관찰치료전후LDL-C화hs-CRP수평적변화급불량반응。결과여대조조상비，치료조환자적신경공능결손명현개선，일상생활활동능력명현개선（P<0.05）。여대조조비교，치료후량조LDL-C화hs-CRP균명현개선（P<0.05），여대조조상비，치료조LDL-C화hs-CRP균명현하강（P<0.05）。결론조기강복연합주사용혈전통동간분용우치료급성뇌경사유현저적료효，병능강저환자LDL-C화hs-CRP수평。
Objective To investigate the clinical effect of Xueshuantong injection combined with early rehabilitation on neurologic function and the influence on blood lipids concentration and high sensitive C-reactive protein in patients with acute cerebral infarction. Methods Totally 120 acute cerebral infarction patients were recruited and randomly di-vided into two groups. The control group was treated with normal therapeutic regimen plus 0.9% normal saline ,the treatment group was given early rehabilitation and xueshuantong injection (0.5g per day), in addition to normal thera-peutic regimen. Treatment duration was 21 days.Their neurologic function impairments and daily living abilities were assessed with the NIHSS and Modified Barthel Index (MBI),The blood lipids concentration and the level of hs-CRP were measured before and after therapy. Results The NIHSS score was significantly lower and the MBI score was sig-nificantly higher in the treatment group on day 7 and 21 after treatment than before treatment(P<0.05).The blood lipids concentration decreased significantly in two groups after drug administration (P<0.05). LDL-C and hs-CRP levels of the treatment group were significantly lower (P<0.05). Conclusion Xueshuantong injection combined with early reha-bilitation may improve neurologic functions and modulate blood lipids and hs-CRP in patients with acute cerebral in-farction.