中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
18期
71-74
,共4页
地佐辛%舒芬太尼%结直肠癌%术后镇痛
地佐辛%舒芬太尼%結直腸癌%術後鎮痛
지좌신%서분태니%결직장암%술후진통
Dezocine%Sufentanil%Colorectal cancer%Postoperative analgesia
目的：探讨地佐辛复合舒芬太尼对结直肠癌患者术后镇痛效果。方法选取2011年1月～2013年6月于本医院治疗的择期行结肠癌、直肠癌根治手术患者68例，随机分为对照组和观察组，每组34例，对照组患者术后给予单纯的舒芬太尼镇痛，观察组患者术后给予地佐辛复合舒芬太尼给患者镇痛，比较两组患者的2h，6h，12h，24h，48 h的VAS和Ramsay镇静评分及镇痛期间的不良反应发生率。结果两组患者的性别比例、年龄分布、体重、ASA分级、手术时间的差异均无统计学意义（P>0.05）；两组患者的不同时间点的VAS评分比较的差异均无统计学意义（P>0.05）；两组患者的不同时间点的Ramsay评分比较的差异均具有统计学意义（P<0.05）；两组患者镇痛期间的不良反应发生率（嗜睡、恶心呕吐和尿潴留）的差异具有统计学意义（P<0.05）。结论采用地佐辛复合舒芬太尼对结直肠癌患者术后镇痛效果明显，临床不良反应较少，安全性较好，且明显优于单纯舒芬太尼的临床应用效果，值得临床推广。
目的：探討地佐辛複閤舒芬太尼對結直腸癌患者術後鎮痛效果。方法選取2011年1月～2013年6月于本醫院治療的擇期行結腸癌、直腸癌根治手術患者68例，隨機分為對照組和觀察組，每組34例，對照組患者術後給予單純的舒芬太尼鎮痛，觀察組患者術後給予地佐辛複閤舒芬太尼給患者鎮痛，比較兩組患者的2h，6h，12h，24h，48 h的VAS和Ramsay鎮靜評分及鎮痛期間的不良反應髮生率。結果兩組患者的性彆比例、年齡分佈、體重、ASA分級、手術時間的差異均無統計學意義（P>0.05）；兩組患者的不同時間點的VAS評分比較的差異均無統計學意義（P>0.05）；兩組患者的不同時間點的Ramsay評分比較的差異均具有統計學意義（P<0.05）；兩組患者鎮痛期間的不良反應髮生率（嗜睡、噁心嘔吐和尿潴留）的差異具有統計學意義（P<0.05）。結論採用地佐辛複閤舒芬太尼對結直腸癌患者術後鎮痛效果明顯，臨床不良反應較少，安全性較好，且明顯優于單純舒芬太尼的臨床應用效果，值得臨床推廣。
목적：탐토지좌신복합서분태니대결직장암환자술후진통효과。방법선취2011년1월～2013년6월우본의원치료적택기행결장암、직장암근치수술환자68례，수궤분위대조조화관찰조，매조34례，대조조환자술후급여단순적서분태니진통，관찰조환자술후급여지좌신복합서분태니급환자진통，비교량조환자적2h，6h，12h，24h，48 h적VAS화Ramsay진정평분급진통기간적불량반응발생솔。결과량조환자적성별비례、년령분포、체중、ASA분급、수술시간적차이균무통계학의의（P>0.05）；량조환자적불동시간점적VAS평분비교적차이균무통계학의의（P>0.05）；량조환자적불동시간점적Ramsay평분비교적차이균구유통계학의의（P<0.05）；량조환자진통기간적불량반응발생솔（기수、악심구토화뇨저류）적차이구유통계학의의（P<0.05）。결론채용지좌신복합서분태니대결직장암환자술후진통효과명현，림상불량반응교소，안전성교호，차명현우우단순서분태니적림상응용효과，치득림상추엄。
Objective To investigate the postoperative analgesic effect of dezocine and sufentanil in patients with col-orectal cancer. Methods Sixty-eight cases with colon cancer, rectal cancer undergoing radical operation in our hospital from January 2011 to June 2013, were randomLy divided into control group and observation group, 34 patients in each group, the patients in control group were given sufentanil analgesia after surgery, and patients in the observation group were given dezocine and sufentanil for analgesia. The VAS and Ramsay sedation score in 2h, 6h, 12h, 24h, 48h and the incidence ratio of adverse reaction during analgesia were compared in two groups. Results There was no statistical significance in the difference of the two groups of sex ratio, age distribution, body weight, ASA classification (P>0.05);there was no significnt difference in VAS scores between the two groups at different time points (P>0.05);There were statistically significant in differences of Ramsay scores among different time points of two groups (P<0.05);There were statistically significant in differences of the incidence ratio of adverse reaction of two groups during analgesia (drowsiness, nausea and vomiting, urinary retention) (P<0.05). Conclusion Analgesic effect of using dezocine and sufentanil with less adverse reaction, good safety is obvious better than sufentanil only in the patients with colorectal cancer after operation, and is worth the clinical promotion.
