CAJ | 학술논문

目的：探讨盐酸司维拉姆联合血液透析滤过对肾性骨病的影响。方法69例肾性骨病患者均于2012年7月～2013年11月在我院治疗，按照治疗方法分成3组各23例，对照A 组接受口服盐酸司维拉姆治疗，对照B组接受血液透析滤过，治疗组接受口服盐酸司维拉姆及血液透析滤过，比较三组疗效、治疗前后常用生化指标。结果治疗组总有效率明显高于对照组A组及对照组B组，差异有统计学意义（P＜0.05）。三组治疗后血Ca水平高于治疗前，P、钙磷乘积、ALP、β-MG、PTH均低于治疗前，差异有统计学意义（P＜0.05）。治疗组的Ca水平高于对照A组及对照B组，P、钙磷乘积、ALP、β-MG、PTH均低于对照A组及对照B组，差异有统计学意义（P＜0.05）。结论采用盐酸司维拉姆联合血液透析滤过治疗肾性骨病疗效明显，可以临床推广应用。
목적：탐토염산사유랍모연합혈액투석려과대신성골병적영향。방법69례신성골병환자균우2012년7월～2013년11월재아원치료，안조치료방법분성3조각23례，대조A 조접수구복염산사유랍모치료，대조B조접수혈액투석려과，치료조접수구복염산사유랍모급혈액투석려과，비교삼조료효、치료전후상용생화지표。결과치료조총유효솔명현고우대조조A조급대조조B조，차이유통계학의의（P＜0.05）。삼조치료후혈Ca수평고우치료전，P、개린승적、ALP、β-MG、PTH균저우치료전，차이유통계학의의（P＜0.05）。치료조적Ca수평고우대조A조급대조B조，P、개린승적、ALP、β-MG、PTH균저우대조A조급대조B조，차이유통계학의의（P＜0.05）。결론채용염산사유랍모연합혈액투석려과치료신성골병료효명현，가이림상추엄응용。
Objective To investigate the effect of sevelamer hydrochloride combined hemodiafiltration on renal os-teodystrophy. Methods A total of 69 cases with renal osteodystrophy were selected from July 2012 to November 2013 in our hospital, they were divided into three groups according to the treatment ,23 cases in each group, the control A group received sevelamer hydrochloride oral treatment, the control B group accepted hemodiafiltration, the treatment group received oral secretary hydrochloride and hemodiafiltration. The efficacy and common biochemical parameters before and after treatment of the three groups were compared. Results The total effective rate of the treatment group was significantly higher than that of the control A group and control B group, the difference was significant(P<0.05). The serum Ca levels of three groups after treatment were higher than before treatment, P, calcium-phosphorus product, ALP, β-MG, PTH were lower than before treatment, the difference was significant (P<0.05). Ca levels in the treatment group were higher than that in the control A group and control B group, P, calcium-phosphorus product, ALP, β-MG, PTH were lower than the control A group and control B group, the difference was significant(P<0.05). Conclusion Seve-lamer hydrochloride combined treatment of renal osteodystrophy hemodiafiltration obvious effect, can clinical applica-tion.