CAJ | 학술논문

目的：探讨盐酸美金刚联合多奈哌齐治疗中、重度阿尔茨海默病（AD）的临床疗效及安全性。方法将86例AD 患者随机分为盐酸美金刚联合多奈哌齐组（实验组）和多奈哌齐组（对照组），在治疗前、治疗后24周末分别利用简易智能状态检查（MMSE）评分量表、AD评估量表-认知部分（ADAS-cog）、日常生活能力（ADL）量表和神经精神症状问卷（NPI）评估。结果实验组和对照组在治疗前后ADAS-cog、ADL和NPI及MMSE差异均有统计学意义（P<0．01），实验组的NPI评分变化高于对照组（P<0．05）。两组不良反应事件发生率差异无统计学意义（P>0．05）。结论实验组和对照组对AD认知功能均有改善，但前者对NPI的改善更明显，两组治疗均具有良好的安全性。
목적：탐토염산미금강연합다내고제치료중、중도아이자해묵병（AD）적림상료효급안전성。방법장86례AD 환자수궤분위염산미금강연합다내고제조（실험조）화다내고제조（대조조），재치료전、치료후24주말분별이용간역지능상태검사（MMSE）평분량표、AD평고량표-인지부분（ADAS-cog）、일상생활능력（ADL）량표화신경정신증상문권（NPI）평고。결과실험조화대조조재치료전후ADAS-cog、ADL화NPI급MMSE차이균유통계학의의（P<0．01），실험조적NPI평분변화고우대조조（P<0．05）。량조불량반응사건발생솔차이무통계학의의（P>0．05）。결론실험조화대조조대AD인지공능균유개선，단전자대NPI적개선경명현，량조치료균구유량호적안전성。
Objective To discuss the effects and security of memantine and donepezil in the treatment of moderate to severe Alzheimer’s disease(AD). Methods Eighty-six AD patients were randomly divided into two groups, the obser-vation group was treated by memantine and donepezil, while the control group was treated by donepezil. The mini-mental state examination (MMSE), ADAS-cog, ADL, NPI were used to evaluate the clinical effects before and after treatment 24 weeks. Results The scores of ADAS-cog,ADL,NPI and MMSE were great significant(P<0.01) in two groups before and after the treatment, the changes of NPI scores in the observation group were significantly higher than in control group (P<0.05),but the adverse reaction of two groups had no significantly difference(P>0.05). Conclusion Both of the two groups have clinical effect on treatment of AD,but memantine and donepezil is better efficacy than donepezil in NPI, and they are all safe.