中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
18期
39-41
,共3页
双歧三联活菌胶囊%溃疡性结肠炎%CD4+%CD24+调节T细胞%白介素-10
雙歧三聯活菌膠囊%潰瘍性結腸炎%CD4+%CD24+調節T細胞%白介素-10
쌍기삼련활균효낭%궤양성결장염%CD4+%CD24+조절T세포%백개소-10
Probiotics capsules%Ulcerative colitis%CD4+,CD24+regulatory T cells%Interleukin-10
目的：研究双歧三联活菌胶囊对溃疡性结肠炎患者CD4+、CD24+调节T细胞及IL-10水平的影响。方法选取134例溃疡性结肠炎患者作为临床研究资料，按照随机对照原则将入组患者分为观察组和对照组，各67例，对照组患者采用常规基础治疗，观察组在对照组治疗基础上采用双歧三联活菌胶囊治疗。比较两组患者的疗效及血清CD4+、CD24+调节T细胞及IL-10水平。结果观察组患者的临床症状评分下降百分比显著高于对照组，两组患者治疗后的结肠炎症评分均显著低于治疗前，而组间比较显示观察组患者治疗后的结肠炎症评分均显著低于对照组。两组患者治疗后的血清CD4+、CD24+调节T细胞占CD4+T细胞的百分比及IL-10水平均较治疗前显著升高，组间比较发现观察组患者治疗后的血清CD4+、CD24+调节T细胞占CD4+T细胞的百分比及IL-10水平均显著高于对照组。结论双歧三联活菌胶囊辅助治疗溃疡性结肠炎患者可以通过调节CD4+、CD24+调节T细胞及IL-10水平。
目的：研究雙歧三聯活菌膠囊對潰瘍性結腸炎患者CD4+、CD24+調節T細胞及IL-10水平的影響。方法選取134例潰瘍性結腸炎患者作為臨床研究資料，按照隨機對照原則將入組患者分為觀察組和對照組，各67例，對照組患者採用常規基礎治療，觀察組在對照組治療基礎上採用雙歧三聯活菌膠囊治療。比較兩組患者的療效及血清CD4+、CD24+調節T細胞及IL-10水平。結果觀察組患者的臨床癥狀評分下降百分比顯著高于對照組，兩組患者治療後的結腸炎癥評分均顯著低于治療前，而組間比較顯示觀察組患者治療後的結腸炎癥評分均顯著低于對照組。兩組患者治療後的血清CD4+、CD24+調節T細胞佔CD4+T細胞的百分比及IL-10水平均較治療前顯著升高，組間比較髮現觀察組患者治療後的血清CD4+、CD24+調節T細胞佔CD4+T細胞的百分比及IL-10水平均顯著高于對照組。結論雙歧三聯活菌膠囊輔助治療潰瘍性結腸炎患者可以通過調節CD4+、CD24+調節T細胞及IL-10水平。
목적：연구쌍기삼련활균효낭대궤양성결장염환자CD4+、CD24+조절T세포급IL-10수평적영향。방법선취134례궤양성결장염환자작위림상연구자료，안조수궤대조원칙장입조환자분위관찰조화대조조，각67례，대조조환자채용상규기출치료，관찰조재대조조치료기출상채용쌍기삼련활균효낭치료。비교량조환자적료효급혈청CD4+、CD24+조절T세포급IL-10수평。결과관찰조환자적림상증상평분하강백분비현저고우대조조，량조환자치료후적결장염증평분균현저저우치료전，이조간비교현시관찰조환자치료후적결장염증평분균현저저우대조조。량조환자치료후적혈청CD4+、CD24+조절T세포점CD4+T세포적백분비급IL-10수평균교치료전현저승고，조간비교발현관찰조환자치료후적혈청CD4+、CD24+조절T세포점CD4+T세포적백분비급IL-10수평균현저고우대조조。결론쌍기삼련활균효낭보조치료궤양성결장염환자가이통과조절CD4+、CD24+조절T세포급IL-10수평。
Objective To observe bifidobacteria triple capsule on the levels of CD4+, CD24+regulatory T cells and IL-10 for patients with ulcerative colitis. Methods Selected 134 cases of patients with ulcerative colitis clinical research data beds, in accordance with the principles of the randomized patients were divided into observation group and control group, with 67 cases in each. Control patients received conventional basic therapy, observation group received probiotics in capsule treatment on the basis of the control group. The efficacy of the two groups of patients and levels of serum CD4+, CD24+ T cells and IL-10 were compared. Results The patients in clinical symptom scores decreased significantly higher percentage, two groups of patients after treatment colitis disease scores were significantly lower than before treatment, and display observed between the two groups of patients after treatment colitis disease scores were significantly lower than the control group. Two groups of patients after treatment serum CD4 +, CD24 +regulatory T cells was significantly higher in CD4+T cells and the percentage of IL-10 levels than before treatment. Conclusion Probiotics capsules adjuvant treatment of ulcerative colitis patients can be adjusted by CD4 +, CD24 +regulatory T cells and IL-10 levels.
