CAJ | 학술논문

目的：探讨避孕方式与宫颈人乳头瘤病毒（H PV ）感染的关系，分析节育环对患者肿瘤坏死因子（T N F-α）的影响。方法2011年6月至2013年6月收治的2576例患者作为研究对象，其中宫颈 H PV感染的患者120例，统计所有避孕方式，对比分析不同避孕方法致患者宫颈 H PV 感染的差异。采用酶联免疫吸附试验（ELISA）检测宫内节育器的50例女性（健康对照组）和无宫内节育器的50例女性（研究组）的宫颈黏液中 TNF-α。结果宫内节育器组感染比例最低，感染率1．92％（10/542），与宫内节育器组比较，避孕套组、口服避孕药组 H PV感染病例均高于宫内节育器组，差异有统计学意义（P＜0．05），输卵管结扎组HPV感染病例高于口服避孕药组，差异有统计学意义（P＜0．05）。研究组宫颈黏液的 TNF-α为（88．94±35．78）pg/mL ，健康对照组为（14．67±6．31） pg/mL ，研究组明显高于健康对照组，差异有统计学意义（P＜0．05），但不同材质的宫内节育器亚组间TNF-α比较，差异无统计学意义（P＞0．05）。结论采取宫内节育器避孕方式的女性 HPV感染比例较小，但宫颈黏液 TNF-α水平较高，节育器可能通过改善局部免疫状态起到预防 H PV感染的作用。
목적：탐토피잉방식여궁경인유두류병독（H PV ）감염적관계，분석절육배대환자종류배사인자（T N F-α）적영향。방법2011년6월지2013년6월수치적2576례환자작위연구대상，기중궁경 H PV감염적환자120례，통계소유피잉방식，대비분석불동피잉방법치환자궁경 H PV 감염적차이。채용매련면역흡부시험（ELISA）검측궁내절육기적50례녀성（건강대조조）화무궁내절육기적50례녀성（연구조）적궁경점액중 TNF-α。결과궁내절육기조감염비례최저，감염솔1．92％（10/542），여궁내절육기조비교，피잉투조、구복피잉약조 H PV감염병례균고우궁내절육기조，차이유통계학의의（P＜0．05），수란관결찰조HPV감염병례고우구복피잉약조，차이유통계학의의（P＜0．05）。연구조궁경점액적 TNF-α위（88．94±35．78）pg/mL ，건강대조조위（14．67±6．31） pg/mL ，연구조명현고우건강대조조，차이유통계학의의（P＜0．05），단불동재질적궁내절육기아조간TNF-α비교，차이무통계학의의（P＞0．05）。결론채취궁내절육기피잉방식적녀성 HPV감염비례교소，단궁경점액 TNF-α수평교고，절육기가능통과개선국부면역상태기도예방 H PV감염적작용。
Objective To investigate the relations of contraception methods and cervical human papillomavirus (HPV) infection ,and analyzes the impact of IUD on patients′s TNF-α.Methods From June 2011 to June 2013 , 2 576 patients were treated as research subjects ,including cervical HPV infection in 120 patients ,all methods of con-traception were statisticed ,different cervical HPV infection Infection rates in patients with dfferent contraceptive methods were compared .The TNF-αwere checked by ELISA on 50 cases IUD patients(study group)and 50 cases no IUD women(control group) .Results IUD group had the lowest proportion infection rate ,the HPV infection rate was 1 .92% (10/542) ,compared with the IUD ,condoms group ,oral contraceptives group(P<0 .05) ,HPV infection rate in the pill group were higher than that of the intrauterine device group ,the difference was statistically significant (P<0 .05) ,tubal ligation HPV infection rate is higher than that of pill group ,difference was statistically significant (P<0 .05) .TNF-αin study Group cervical mucus was(88 .94 ± 35 .78) pg/mL ,that of control group was(14 .67 ± 6 .31) pg/mL ,the study group was significantly higher(P<0 .05) ,but there was no significant difference in different materials IUD of control subgroups(P>0 .05) .Conclusion The women with IUD contraception has a small propor-tion HPV infection ,but the TNF-αof cervical mucus is higher .It may play a role in the prevention of HPV infection by improving the local immune status .