CAJ | 학술논문

目的探讨气管内滴注肺表面活性物质治疗新生儿肺透明膜病的效果及安全性.方法选择新生儿肺透明膜病患儿67例,采用气管内注入单剂肺表面活性物质治疗,观察患儿治疗前后的临床表现、血气、X线胸片以及并发症情况.结果痊愈出院65例(97.01％),死亡2例;给药后患儿氧分压(PO2)和动脉血氧饱和度(SaO2)明显升高(P＜0.05),二氧化碳分压(PCO2)明显下降(P＜0.05),皮肤发绀、青紫状况缓解.24 h内复查胸片示肺野透明情况显著改善62例(92.54％),无明显改善4例(5.97％),有合并肺出血影像1例(1.49％).共发生并发症5例,其中肺炎3例,颅内出血1例,肺出血1例.结论早期应用肺表面活性物质能快速改善肺透明膜病患儿的临床症状,改善肺氧合功能,降低对机械通气的需求,有效减少并发症的发生及病死率.
목적 탐토기관내적주폐표면활성물질치료신생인폐투명막병적효과급안전성.방법 선택신생인폐투명막병환인67례,채용기관내주입단제폐표면활성물질치료,관찰환인치료전후적림상표현、혈기、X선흉편이급병발증정황.결과 전유출원65례(97.01％),사망2례;급약후환인양분압(PO2)화동맥혈양포화도(SaO2)명현승고(P＜0.05),이양화탄분압(PCO2)명현하강(P＜0.05),피부발감、청자상황완해.24 h내복사흉편시폐야투명정황현저개선62례(92.54％),무명현개선4례(5.97％),유합병폐출혈영상1례(1.49％).공발생병발증5례,기중폐염3례,로내출혈1례,폐출혈1례.결론 조기응용폐표면활성물질능쾌속개선폐투명막병환인적림상증상,개선폐양합공능,강저대궤계통기적수구,유효감소병발증적발생급병사솔.
Objective To study the efficacy and safety of pulmonary surfactant used in hyaline membrane disease(HMD)of newborn treatment.Methods 67 cases of HMD children were treated.And pulmonary surfactant was used by intratracheal instillation.Clinical manifestation,blood gas analysis,X-ray chest film and complication before and after treatment were observed and recorded.Results 65 cases of children were recovered and discharged(97.01％),while 2 cases were dead.The PO2 increased significantly after the surfactant was given(P＜0.05),while the PCO2 decreased significantly(P＜0.05),and situation of skin cyanosis was relieved.X-ray chest films in 24 hours showed that 62 cases were improved(92.54％),while 4 cases were not obvious(5.97％),and there was hemorrhage image in the last 1 caes(1.49％).There were 5 cases of complication,involving 3 cases of pneumonia,1 case of intracranial hemorrhage and 1 case of pulmonary hemorrhage.Conclusion Clinical symptoms could be impurved rapidly,pulmonary oxygenation could be ameliorated,the need of mechanical ventilation could be lower and the rate of incidence of complication and death could be reduced effectively by using pulmonary surfactant early.