CAJ | 학술논문

目的：观察匹伐他汀的降糖效果及其治疗糖尿病高胆固醇血症的疗效。方法选取2012年1月至2013年3月就诊治疗的106例糖尿病高胆固醇血症患者作为研究对象，随机分为对照组和观察组各53例。所有患者在服用二甲双胍降糖药和控制饮食治疗的同时，对照组给予口服阿托伐他汀药物治疗，观察组给予匹伐他汀药物治疗，比较分析两种药物的降糖效果及降脂效果。结果与治疗前比较，观察组空腹血糖（ FBS）和糖化血红蛋白（ HbA1c）均显著降低（ P <0.05），对照组FBS、餐后血糖（ PBG）、HbA1c变化均无显著性差异（ P >0.05）；治疗后观察组FBS、HbA1c与对照组相比差异具有显著性（ P <0.05），而PBG两组比较差异无显著性（ P >0.05）。两组患者治疗前后总胆固醇（ TC）、三酰甘油（ TG）、低密度脂蛋白胆固醇（ LDL-C）和高密度脂蛋白胆固醇（ HDL-C）比较差异均具有显著性（ P <0.05），治疗后观察组TC、TG和LDL分别降低了10.41％、17.92％和12.98％，对照组TC、TG和LDL-C分别降低了9.94％、15.97％和13.46％，组间比较差异无统计学意义（ P >0.05）；而观察组HDL-C升高达9.12％，对照组HDL-C升高6.31％，观察组明显高于对照组，组间比较差异具有统计学意义（ P <0.05）。观察组不良反应发生率为3.77％，对照组不良反应发生率为7.55％，组间比较差异无显著性（ P >0.05）。结论匹伐他汀能够增加高密度脂蛋白胆固醇水平，而且对患者FBS和HbA1c的降低作用优于阿托伐他汀，是一种安全有效的治疗糖尿病高胆固醇血症的药物，值得临床广泛应用。
목적：관찰필벌타정적강당효과급기치료당뇨병고담고순혈증적료효。방법선취2012년1월지2013년3월취진치료적106례당뇨병고담고순혈증환자작위연구대상，수궤분위대조조화관찰조각53례。소유환자재복용이갑쌍고강당약화공제음식치료적동시，대조조급여구복아탁벌타정약물치료，관찰조급여필벌타정약물치료，비교분석량충약물적강당효과급강지효과。결과여치료전비교，관찰조공복혈당（ FBS）화당화혈홍단백（ HbA1c）균현저강저（ P <0.05），대조조FBS、찬후혈당（ PBG）、HbA1c변화균무현저성차이（ P >0.05）；치료후관찰조FBS、HbA1c여대조조상비차이구유현저성（ P <0.05），이PBG량조비교차이무현저성（ P >0.05）。량조환자치료전후총담고순（ TC）、삼선감유（ TG）、저밀도지단백담고순（ LDL-C）화고밀도지단백담고순（ HDL-C）비교차이균구유현저성（ P <0.05），치료후관찰조TC、TG화LDL분별강저료10.41％、17.92％화12.98％，대조조TC、TG화LDL-C분별강저료9.94％、15.97％화13.46％，조간비교차이무통계학의의（ P >0.05）；이관찰조HDL-C승고체9.12％，대조조HDL-C승고6.31％，관찰조명현고우대조조，조간비교차이구유통계학의의（ P <0.05）。관찰조불량반응발생솔위3.77％，대조조불량반응발생솔위7.55％，조간비교차이무현저성（ P >0.05）。결론필벌타정능구증가고밀도지단백담고순수평，이차대환자FBS화HbA1c적강저작용우우아탁벌타정，시일충안전유효적치료당뇨병고담고순혈증적약물，치득림상엄범응용。
Objective To observe the efficacy of pitavastatin and its effect on blood glucose in diabetic treatment of hypercholesterolemia. Methods 106 cases of diabetic patients with hypercholesterolemia were selected from our hospital between January 2012 and March 2012 during clinic treatment. All of these patients were randomly divided into control group and observation group,53 cases in each group. All patients took metformin hypoglycemic agents and diet therapy at the same time. The control group received oral atorvastatin therapy. Observation group were giv-en pitavastatin medication. The blood sugar effects and efficacy were compared and analyzed in the two drugs for the treatment of. Results Com-pared with before treatment,FBS and HbA1c in observation group were significantly lower( P <0. 05). FBS,PBG,HbA1c change of the control group had no significant difference( P >0. 05). After treatment observation group had significant difference in FBS and HbA1c compared with control group( P <0. 05). The PBG was similar between the two groups. There was no significant difference( P >0. 05). Two groups of pa-tients,the differences of before and after treatment the TC,TG,LDL-C and HDL-C were significant( P <0. 05). After treatment,TC,TG and LDL in the observation group was reduced by 10. 41%,17. 92% and 12. 98%,respectively. The TC,TG and LDL-C of the control group reduced by 9. 94%,15. 97% and 13. 46%,respectively. Comparing the differences between groups,there was no statistical significance( P >0. 05). But HDL-C of the observation group raised by 9. 12%. The HDL-C of the control group raised by 6. 31%. The observation group was significantly higher than the control group. Difference between groups was statistically significant( P <0. 05). In observation group,the inci-dence of adverse reactions was 3. 77%. The incidence of control group was 7. 55%. By comparing differences,there was no statistical significance ( P >0. 05). Conclusion Pitavastatin can increase high-density lipoprotein cholesterol levels,but also reduce and control of fasting blood glu-cose fluctuations in blood sugar levels than atorvastatin. It is a safe and effective treatment for diabetes,hypercholesterolemia drug,worthy of wider application.