CAJ | 학술논문

目的：观察进展性脑梗死患者血清超敏C反应蛋白（hs-CRP）和神经元特异性烯醇化酶（NSE）的水平，探讨其在进展性脑梗死中的临床应用价值。方法检测44例进展性脑梗死（进展组）和42例非进展性脑梗死患者（非进展组）的第2天、第4天、第8天血清hs-CRP和NSE水平，并作对照。结果第2日进展组hs-CRP水平（2．98±0．46 mg/mL）与非进展组（2．95±0．55 mg/mL）比较差异无统计学意义（P＞0．05）；第4日进展组hs-CRP水平（5．58±0．41 mg/mL）明显高于非进展组（2．84±0．51 mg/mL），两组比较差异有统计学意义（P＜0．05）；第8日进展组hs-CRP水平（3．51±0．52 mg/mL）与非进展组（2．96±0．47mg/mL）比较差异无统计学意义（P＞0．05）。第2日进展组NSE水平（16．92±1．45 ng/mL）与非进展组（15．88±1．51 ng/mL）比较差异无统计学意义（P＞0．05）；第4日进展组NSE水平（23．91±2．42 ng/mL）明显高于非进展组（15．79±1．65 ng/mL），两组比较差异有统计意义（P＜0．05）；第8日进展组 NSE 水（17．01±1．58ng/mL）与非进展组（15．97±1．32ng/mL）比较差异无统计学意义（P＞0．05）。结论血清hs-CRP和NSE水平检测对进展性脑梗死的诊断、病情严重程度、预后具有重要参考价值。
목적：관찰진전성뇌경사환자혈청초민C반응단백（hs-CRP）화신경원특이성희순화매（NSE）적수평，탐토기재진전성뇌경사중적림상응용개치。방법검측44례진전성뇌경사（진전조）화42례비진전성뇌경사환자（비진전조）적제2천、제4천、제8천혈청hs-CRP화NSE수평，병작대조。결과제2일진전조hs-CRP수평（2．98±0．46 mg/mL）여비진전조（2．95±0．55 mg/mL）비교차이무통계학의의（P＞0．05）；제4일진전조hs-CRP수평（5．58±0．41 mg/mL）명현고우비진전조（2．84±0．51 mg/mL），량조비교차이유통계학의의（P＜0．05）；제8일진전조hs-CRP수평（3．51±0．52 mg/mL）여비진전조（2．96±0．47mg/mL）비교차이무통계학의의（P＞0．05）。제2일진전조NSE수평（16．92±1．45 ng/mL）여비진전조（15．88±1．51 ng/mL）비교차이무통계학의의（P＞0．05）；제4일진전조NSE수평（23．91±2．42 ng/mL）명현고우비진전조（15．79±1．65 ng/mL），량조비교차이유통계의의（P＜0．05）；제8일진전조 NSE 수（17．01±1．58ng/mL）여비진전조（15．97±1．32ng/mL）비교차이무통계학의의（P＞0．05）。결론혈청hs-CRP화NSE수평검측대진전성뇌경사적진단、병정엄중정도、예후구유중요삼고개치。
Objective To observe the progress of patients with cerebral infarction serum high sensitivity C-reactive protein (hs-CRP)and neuron-specific enolase (NSE)levels to explore its progressive cerebral infarction in clinical applications.Methods Serum NSE and hs-CRP levels on 2nd day,4th day and 8th day of 44 cases (progression group)and 42 patients with non-progressive cerebral infarction (non-progression group)were compared.Results The difference in hs-CRP levels on 2nd day was not significant statistically in progression (2.98 ±0.46 mg /mL)and non-progression group (2.95 ±0.55 mg/mL)(P>0.05 );hs-CRP levels on 4th day in progression group (5.58 ±0.41 mg/mL)was significantly higher than those in non-progression group (2.84 ±0.51 mg/mL),and the difference was statistical-ly significant (P<0.05);the difference in hs-CRP levels on 8th day was not significant statistically significant in progression group(3.51 ± 0.52 mg /mL)and non-progression group (2.96 ±0.47mg/mL)(P>0.05).NSE levels on 2nd day had no statistically significant differ-ence in progression group (16.92 ±1.45 mg /mL)and non-progressive group (15.88 ±1.51 mg /mL)(P>0.05);NSE levels on 4th day was significantly higher in progression group (23.91 ±2.42 ng /mL)than in non-progression group (15.79 ±1.65 mg /mL),and the difference was statistically significant (P<0.05);the difference in NSE levels on 8th day in progression group (17.01 ±1.58 mg/mL)and non-progressive group (15.97 ±1.32 mg/mL)was not significant statistically significant (P>0.05).Conclusion hs-CRP and NSE levels have important reference value in the diagnosis of progressive cerebral infarction,and in determining the severity of illness and the prognosis.