国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2013年
4期
251-253
,共3页
王光明%张叶娜%石宁藉%雷涛
王光明%張葉娜%石寧藉%雷濤
왕광명%장협나%석저자%뢰도
喹诺酮类%下呼吸道感染%左氧氟沙星
喹諾酮類%下呼吸道感染%左氧氟沙星
규낙동류%하호흡도감염%좌양불사성
Quinolones%Lower respiratory tract infections%Levofloxacin
目的 探讨高剂量左氧氟沙星静脉注射液治疗常见下呼吸道感染的临床疗效.方法 回顾性分析宁波市第二医院2010年5月至2012年6月收治的166例下呼吸道感染患者的临床资料,其中肺炎89例,慢性阻塞性肺炎加重期45例,支气管扩张症32例.所有患者均予滴注高剂量(600 mg/d)左氧氟沙星注射液进行治疗,7～14d为1个疗程.观察其临床疗效及不良反应发生情况.结果 166例患者发热、咳嗽、咳痰及肺部啰音等临床症状平均缓解时间均不超过5.0d,三类患者WBC均下降(t=4.26、5.38、5.74,P均＜0.05),肝肾功能无损伤；平均治疗时间为7.9d,总有效率为83.7％.共检出细菌42株,治疗后36株被清除,清除率为85.7％.不良反应发生率为7.2％,均为轻度反应.结论 静脉高剂量左氧氟沙星注射液治疗下呼吸道感染疗效明显,安全性高,患者不良反应发生率低,值得临床推广和应用.
目的 探討高劑量左氧氟沙星靜脈註射液治療常見下呼吸道感染的臨床療效.方法 迴顧性分析寧波市第二醫院2010年5月至2012年6月收治的166例下呼吸道感染患者的臨床資料,其中肺炎89例,慢性阻塞性肺炎加重期45例,支氣管擴張癥32例.所有患者均予滴註高劑量(600 mg/d)左氧氟沙星註射液進行治療,7～14d為1箇療程.觀察其臨床療效及不良反應髮生情況.結果 166例患者髮熱、咳嗽、咳痰及肺部啰音等臨床癥狀平均緩解時間均不超過5.0d,三類患者WBC均下降(t=4.26、5.38、5.74,P均＜0.05),肝腎功能無損傷；平均治療時間為7.9d,總有效率為83.7％.共檢齣細菌42株,治療後36株被清除,清除率為85.7％.不良反應髮生率為7.2％,均為輕度反應.結論 靜脈高劑量左氧氟沙星註射液治療下呼吸道感染療效明顯,安全性高,患者不良反應髮生率低,值得臨床推廣和應用.
목적 탐토고제량좌양불사성정맥주사액치료상견하호흡도감염적림상료효.방법 회고성분석저파시제이의원2010년5월지2012년6월수치적166례하호흡도감염환자적림상자료,기중폐염89례,만성조새성폐염가중기45례,지기관확장증32례.소유환자균여적주고제량(600 mg/d)좌양불사성주사액진행치료,7～14d위1개료정.관찰기림상료효급불량반응발생정황.결과 166례환자발열、해수、해담급폐부라음등림상증상평균완해시간균불초과5.0d,삼류환자WBC균하강(t=4.26、5.38、5.74,P균＜0.05),간신공능무손상；평균치료시간위7.9d,총유효솔위83.7％.공검출세균42주,치료후36주피청제,청제솔위85.7％.불량반응발생솔위7.2％,균위경도반응.결론 정맥고제량좌양불사성주사액치료하호흡도감염료효명현,안전성고,환자불량반응발생솔저,치득림상추엄화응용.
Objective To evaluate the clinical efficacy of high-dose levofloxacin injection for treatment of lower respiratory tract infections.Methods The clinical data of 166 patients with lower respiratory tract infections received in the Second Hospital of Ningbo from May 2012 to June 2012 were retrospectively analyzed.Among these patients,there were 89 pneumonia cases,45 chronic obstructive pulmonary disease (COPD) cases and 32 bronchiectasis cases.All patients were treated with high-dose levofloxacin (600 mg/d) for 7-14 days as one course of treatment.The clinical curative effect and adverse reaction were observed.Results The mean remission time of fever,cough,expectoration and pulmonary rales were less than 5 days in 166 cases.WBC decreased in all the pneumoina,COPD,bronchiectasis cases(t =4.26,5.38,5.74,P ＜ 0.05),no liver and kidney function damage was found.The average treatment time was 7.9 days,and the effective rate was 83.7 ％.A total of 42 bacteria isolations were detected before treatment,and 36 bacteria isolations were cleared after treatment.The clearance rate was 85.7 ％.The adverse reaction rate was 7.2 ％,and all were mild.Conclusions Intravenous injection of high-dose levofloxacin for treatment of lower respiratory tract infections is effective and safe with a low incidence of adverse reactions.It is worth of clinical generalization and applications.
