CAJ | 학술논문

　　目的探讨右美托咪定镇静在慢性阻塞性肺疾病(COPD)急性发作呼吸衰竭中的临床疗效。方法2011年6月-2012年6月我院收治的COPD呼吸衰竭行有创机械通气治疗的患者30例，随机分为右美托咪定镇静组(试验组)和咪达唑仑组(对照组)，比较两组镇静效果。结果试验组平均血压、心率、血氧饱和度与对照组无明显差异(P >0.05)；呼吸机使用时间、谵妄、呼吸机相关肺炎的发生率低于咪达唑仑组(P <0.05)。结论 COPD急性加重并呼吸衰竭，使用右美托咪定镇静可以加速患者脱机，改善患者预后。
　　목적탐토우미탁미정진정재만성조새성폐질병(COPD)급성발작호흡쇠갈중적림상료효。방법2011년6월-2012년6월아원수치적COPD호흡쇠갈행유창궤계통기치료적환자30례，수궤분위우미탁미정진정조(시험조)화미체서륜조(대조조)，비교량조진정효과。결과시험조평균혈압、심솔、혈양포화도여대조조무명현차이(P >0.05)；호흡궤사용시간、섬망、호흡궤상관폐염적발생솔저우미체서륜조(P <0.05)。결론 COPD급성가중병호흡쇠갈，사용우미탁미정진정가이가속환자탈궤，개선환자예후。
Objective To investigate the dexmedetomidine given sedation in acute exacerbation of chronic obstructive pulmonary disease(COPD) clinical efficacy in respiratory failure. Method From June 2011 to June 2012 in our hospital with chronic obstructive pulmonary disease and respiratory failure, 30 cases of invasive mechanical ventilation in patients treated using a random number table, were randomly divided into 2 groups, given sedative dexmedetomidine group. Result Test group average blood pressure, heart rate, oxygen saturation and the control group, no significant difference(P >0.05); ventilator time, delirium, ventilator-associated pneumonia incidence is lower than the midazolam group(P <0.05). Conclusions Chronic obstructive pulmonary disease and respiratory failure, the use of dexmedetomidine given a sedative can be accelerated in patients with offline, improved patient outcomes.