CAJ | 학술논문

　　目的探讨显微镜下多血管炎(microscopic polyangiitis，MPA)的临床特征和诊疗方法。方法对我院2008年1月-2012年12月间收治的MPA8例患者临床资料进行回顾性分析。结果8例患者均有肺部损害，伴不同程度的多器官损害，7例患者出现白细胞升高、贫血、镜下血尿、蛋白尿、红细胞管型、肌酐及尿素氮升高，8例患者出现核周型抗中性粒细胞胞浆抗体(primary antineutrophilcytoplasmicantibodies，P-ANCA)阳性，6例患者出现抗髓过氧化物酶( myeloperoxidase，MPO)ANCA阳性。CT表现为双肺弥漫性磨玻璃影为主，4例患者出现肺间质纤维化。6例患者治愈或好转，2例患者恶化或死亡。结论MPA临床表现无特异性，多有肺损害，易误诊，ANCA对MPA的诊断有重要价值。
　　목적탐토현미경하다혈관염(microscopic polyangiitis，MPA)적림상특정화진료방법。방법대아원2008년1월-2012년12월간수치적MPA8례환자림상자료진행회고성분석。결과8례환자균유폐부손해，반불동정도적다기관손해，7례환자출현백세포승고、빈혈、경하혈뇨、단백뇨、홍세포관형、기항급뇨소담승고，8례환자출현핵주형항중성립세포포장항체(primary antineutrophilcytoplasmicantibodies，P-ANCA)양성，6례환자출현항수과양화물매( myeloperoxidase，MPO)ANCA양성。CT표현위쌍폐미만성마파리영위주，4례환자출현폐간질섬유화。6례환자치유혹호전，2례환자악화혹사망。결론MPA림상표현무특이성，다유폐손해，역오진，ANCA대MPA적진단유중요개치。
Objective To investigate the clinical manifestation of microscopic polyangiitis(MPA). Methods Eight microscopic polyangiitis patients complicated with pulmonary involvement from January 2008 to December 2012 were studied retrospectively, admitted to the Jiangmen Central hospital. Results Pulmonary involvement were presented in all patients,and renal symptom in seven patients. Chest CT lesions showed ground-glass opacity and pulmonary fibrosis. 6 out of 8 patients were cured or improved. All patients showed positive MPO-ANCA and 6 of P-ANCA. Conclusion The clinical manifestation of MPA were not specific, and most of the MPA patients complicated with pulmonary involvement. Antineutrophil cytoplasmic antibedy(ANCA) will be of great value to MPA’s diagnosis.