CAJ | 학술논문

　　目的观察细菌溶解产物(泛福舒)防治慢性阻塞性肺疾病急性加重期(AECODP)的疗效。方法76例AECODP患者随机分为两组各38例，对照组给予常规抗炎、平喘、化痰及其对症治疗，观察组在常规治疗基础上给予泛福舒口服；观察并比较两组患者1年内急性发作次数、抗生素使用时间、外周血T淋巴细胞亚群和血清免疫球蛋白的变化。结果观察组1年内急性发作次数、急性发作期间抗生素使用时间均较对照组缩短(P <0.01)，观察组6个月后外周血T淋巴细胞亚群以及IgG、IgA水平与治疗前比较差异有统计学意义(P <0.05)，对照组治疗前后比较差异无统计学意义(P >0.05)。结论应用细菌溶解产物治疗可明显改善慢性阻塞性肺疾病的免疫功能，减少感染急性发作次数。
　　목적관찰세균용해산물(범복서)방치만성조새성폐질병급성가중기(AECODP)적료효。방법76례AECODP환자수궤분위량조각38례，대조조급여상규항염、평천、화담급기대증치료，관찰조재상규치료기출상급여범복서구복；관찰병비교량조환자1년내급성발작차수、항생소사용시간、외주혈T림파세포아군화혈청면역구단백적변화。결과관찰조1년내급성발작차수、급성발작기간항생소사용시간균교대조조축단(P <0.01)，관찰조6개월후외주혈T림파세포아군이급IgG、IgA수평여치료전비교차이유통계학의의(P <0.05)，대조조치료전후비교차이무통계학의의(P >0.05)。결론응용세균용해산물치료가명현개선만성조새성폐질병적면역공능，감소감염급성발작차수。
Objective To observe the preventive effects of bacterial lysates for acute exacerbation of chronic obstructive pulmonary diseases(AECOPD). Method 76 patients with AECOPD were randomly divided into two groups: 38 cases in control group were given conventional anti-inflammatory, relieving asthma, resolving phlegm and symptomatic treatment, The observation group 38 cases on the basis of routine treatment for bacterial lysates to oral; Observation of 2 groups of patients within 1 years the number of acute attack, antibiotic use time, peripheral blood T lymphocyte subgroups and serum immunoglobulin changes, and compare. Results The observation group 1 years the number of acute attack, during an acute episode of antibiotics use time are shorter than in control group(P <0.01), The observation group 6 months after peripheral blood T lymphocyte subsets and IgG, IgA levels before and after treatment had significant difference(P <0.05), The control group before and after treatment there was no statistically significant difference(P >0.05). Conclusion Application of bacterial lysates to treatment could obviously improve the chronic obstructive pulmonary disease immune function, reduce the infection of acute episodes.