中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
9期
24-26
,共3页
糖皮质激素%单纯疱疹病毒性脑炎%预后
糖皮質激素%單純皰疹病毒性腦炎%預後
당피질격소%단순포진병독성뇌염%예후
Glucocorticoid%Herpes simplex virus encephalitis%Prognosis
目的：探讨糖皮质激素治疗对单纯疱疹病毒性脑炎疗效及预后的影响。方法选取2008-07-2013-07于我院临床确诊为单纯疱疹病毒性脑炎的62例患者，在常规综合治疗的基础上，根据是否加用糖皮质激素治疗，将其随机分为观察组和对照组各31例，治疗4周后观察并比较2组患者各项主要临床指标及治疗效果。结果治疗后2组患者在简易精神状态量表（MMSE）评分、颅内压异常、脑脊液白细胞数、脑脊液蛋白质定量、脑膜刺激征阳性、脑电图异常、颅脑CT异常和病程长短等方面与治疗前比较均明显改善，差异有统计学意义（P＜0.05），观察组较对照组改善更明显，差异有统计学意义（P＜0.05）。治疗4周后，观察组总有效率为87.10％，高于对照组的70.98％，差异有统计学意义（ P＜0.05）。结论糖皮质激素治疗单纯疱疹病毒性脑炎疗效肯定，临床应用要合理选择。
目的：探討糖皮質激素治療對單純皰疹病毒性腦炎療效及預後的影響。方法選取2008-07-2013-07于我院臨床確診為單純皰疹病毒性腦炎的62例患者，在常規綜閤治療的基礎上，根據是否加用糖皮質激素治療，將其隨機分為觀察組和對照組各31例，治療4週後觀察併比較2組患者各項主要臨床指標及治療效果。結果治療後2組患者在簡易精神狀態量錶（MMSE）評分、顱內壓異常、腦脊液白細胞數、腦脊液蛋白質定量、腦膜刺激徵暘性、腦電圖異常、顱腦CT異常和病程長短等方麵與治療前比較均明顯改善，差異有統計學意義（P＜0.05），觀察組較對照組改善更明顯，差異有統計學意義（P＜0.05）。治療4週後，觀察組總有效率為87.10％，高于對照組的70.98％，差異有統計學意義（ P＜0.05）。結論糖皮質激素治療單純皰疹病毒性腦炎療效肯定，臨床應用要閤理選擇。
목적：탐토당피질격소치료대단순포진병독성뇌염료효급예후적영향。방법선취2008-07-2013-07우아원림상학진위단순포진병독성뇌염적62례환자，재상규종합치료적기출상，근거시부가용당피질격소치료，장기수궤분위관찰조화대조조각31례，치료4주후관찰병비교2조환자각항주요림상지표급치료효과。결과치료후2조환자재간역정신상태량표（MMSE）평분、로내압이상、뇌척액백세포수、뇌척액단백질정량、뇌막자격정양성、뇌전도이상、로뇌CT이상화병정장단등방면여치료전비교균명현개선，차이유통계학의의（P＜0.05），관찰조교대조조개선경명현，차이유통계학의의（P＜0.05）。치료4주후，관찰조총유효솔위87.10％，고우대조조적70.98％，차이유통계학의의（ P＜0.05）。결론당피질격소치료단순포진병독성뇌염료효긍정，림상응용요합리선택。
Objective To investigate the influence of Glucocorticoid on incidence and prognosis of herpes simplex virus en-cephalitis ,and provide new ideas for the treatment.Methods Sixty-two patients diagnosed as herpes simplex virus encephalitis in our hospital from July 2008 to July 2013 were chosen as the subjects. Based on the conventional treatment ,according to whether treatment with corticosteroids ,they were randomly divided into the observation group and control group ,31 patients in each group.After 4 weeks of treatment ,the main clinical parameters and therapeutic efficacy of the two groups were ob-served and compared. Results After treatment ,Mini-Mental State Examination (MMSE) score ,intracranial abnormalities , white blood cell count in CSF ,cerebrospinal fluid protein quantification ,positive cases of meningeal irritation ,abnormal EEG , brain CT abnormal and other aspects of disease duration were significantly improved compared with those before treatment (P<0.05) ,but the observation group improved more significantly than the control group ,there was a significant difference (P<0.05). After glucocorticoid treatment for 4 weeks ,the total effective rate of observation group was 87.10% ,and was higher than 70.98% of the control group(P<0.05) ,the differean was statistically significant.Conclusion Glucocorticoid for herpes simplex virus encephalitis is effective ,it should be a reasonable choice for clinical applications.
